Frontotemporal dementia

Handbook of Clinical Neurology
Jessica Deleon, Bruce L Miller

Abstract

Frontotemporal dementia (FTD) is a neurodegenerative disorder characterized by progressive changes in behavior, personality, and language with involvement of the frontal and temporal regions of the brain. About 40% of FTD cases have a positive family history, and about 10% of these cases are inherited in an autosomal-dominant pattern. These gene defects present with distinct clinical phenotypes. As the diagnosis of FTD becomes more recognizable, it will become increasingly important to keep these gene mutations in mind. In this chapter, we review the genes with known associations to FTD. We discuss protein functions, mutation frequencies, clinical phenotypes, imaging characteristics, and pathology associated with these genes.

Citations

Nov 14, 2018·Neuropathology and Applied Neurobiology·H ZetterbergJ D Rohrer
Sep 28, 2018·Operative Neurosurgery·Cordell M BakerMichael E Sughrue
Jun 12, 2019·Journal of Neurology, Neurosurgery, and Psychiatry·Stefano GazzinaUNKNOWN Genetic FTD Initiative, GENFI
Jul 8, 2020·The Journal of Law, Medicine & Ethics : a Journal of the American Society of Law, Medicine & Ethics·Jalayne J Arias, Lauren S Flicker
Sep 26, 2020·Dementia & Neuropsychologia·Claudia RamosFrancisco Lopera
Dec 1, 2019·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Nicholas T OlneyUNKNOWN ARTFL and LEFFTDS consortia
Nov 7, 2019·Current Genetic Medicine Reports·Daniel W SirkisJennifer S Yokoyama
Nov 11, 2020·Nature Reviews. Neurology·Carolin A M KoriathSimon Mead
Nov 21, 2020·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Kamen A TsvetanovUNKNOWN Genetic FTD Initiative, GENFI
Feb 5, 2021·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Yaling JiangLu Shen
Jan 30, 2019·Current Opinion in Neurology·Boon Lead Tee, Maria Luisa Gorno-Tempini
Jan 10, 2019·Praxis·David Czell
Sep 6, 2020·Neurobiology of Disease·Suvi HäkkinenSuzee E Lee
May 9, 2021·Journal of Medical Genetics·Lauren M CairnsAndrew G L Douglas
Jun 16, 2021·Wiener medizinische Wochenschrift·Sigrid Klotz, Ellen Gelpi
Aug 15, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Bradley T PeetRenaud La Joie
Sep 3, 2021·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Stefania BasilicoGabriella Bottini
May 22, 2021·Brain : a Journal of Neurology·Terouz PashaFrank Hirth

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