Frozen Section Diagnosis of Ovarian Epithelial Tumors: Diagnostic Pearls and Pitfalls

Archives of Pathology & Laboratory Medicine
Natalia Buza

Abstract

Epithelial tumors of the ovary are one of the most frequently encountered gynecologic specimens in the frozen section laboratory. The preoperative diagnostic workup of an ovarian mass is typically limited to imaging studies and serum markers, both of which suffer from low sensitivity and specificity. Therefore, intraoperative frozen section evaluation is crucial for determining the required extent of surgery, that is, cystectomy for benign tumors, oophorectomy or limited surgical staging for borderline tumors in younger patients to preserve fertility, or extensive staging procedure for ovarian carcinomas. Ovarian epithelial tumors may exhibit a wide range of morphologic patterns, which often overlap with each other and can mimic a variety of other ovarian nonepithelial neoplasms as well. A combination of careful gross examination, appropriate sampling and interpretation of morphologic findings, and familiarity with the clinical context is the key to the accurate frozen section diagnosis and successful intraoperative consultation. To review the salient frozen section diagnostic features of ovarian epithelial tumors, with special emphasis on useful clinicopathologic and morphologic clues and potential diagnostic pitfalls. Review ...Continue Reading

References

Oct 1, 1991·Gynecologic Oncology·I ObiakorR Demopoulos
Aug 1, 1985·The American Journal of Surgical Pathology·R H Young, R E Scully
Dec 15, 1985·Cancer·D A Bell, R E Scully
Apr 1, 1981·The American Journal of Surgical Pathology·A BullónR E Scully
Mar 1, 1984·Cancer·T M UlbrightF B Stehman
Sep 1, 1982·The American Journal of Surgical Pathology·R H YoungR E Scully
Apr 20, 1994·Journal of the National Cancer Institute·J M GuinebretièreG Contesso
Jan 1, 1993·The American Journal of Surgical Pathology·J D SeidmanF A Tavassoli
Jan 1, 1996·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·J D Seidman
Jul 2, 2002·American Journal of Clinical Pathology·Andrew A RenshawMary L Young
Feb 27, 2003·The American Journal of Surgical Pathology·Kenneth R Lee, Robert H Young
Apr 30, 2003·The American Journal of Surgical Pathology·Brigitte M Ronnett, Jeffrey D Seidman
Oct 25, 2003·Science·Mary-Claire KingUNKNOWN New York Breast Cancer Study Group
Apr 16, 2004·Breast Cancer Research : BCR·Grazia ArpinoRichard M Elledge
Aug 26, 2004·The Journal of Obstetrics and Gynaecology Research·Dittakarn Boriboonhirunsarn, Athita Sermboon
Oct 4, 2006·Gynecologic Oncology·Yusuke MatsuuraNeville F Hacker
Mar 18, 2008·The American Journal of Surgical Pathology·Jesse K McKenneyTeri A Longacre
Jul 22, 2008·Gynecologic Oncology·J P OrezzoliA F Fuller
Oct 14, 2009·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Yvonne R P de WaalLeon F A G Massuger
Dec 31, 2009·Cancer·Veronique BigorieEmmanuel Barranger
Jun 15, 2011·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·C Bethan PowellJohn Ziegler
Oct 22, 2011·Human Reproduction·Hiroaki KajiyamaFumitaka Kikkawa
Dec 14, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sohei YamamotoOsamu Matsubara
Dec 24, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Robert A SoslowDouglas A Levine
Mar 27, 2012·Gynecologic Oncology·Cristina SigismondiGiorgia Mangili
Jun 14, 2012·The Journal of Obstetrics and Gynaecology Research·Rani Akhil BhatKwai Lam Yam
Sep 15, 2012·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Ayse AyhanIe-Ming Shih
Nov 3, 2012·American Journal of Obstetrics and Gynecology·Jennifer E LinStephen L Rose

❮ Previous
Next ❯

Citations

Aug 10, 2019·Case Reports in Pathology·Maria Del Mar Rivera RolonCecilia Clement
Aug 11, 2019·Current Problems in Diagnostic Radiology·Veenu SinglaNiranjan Khandelwal
May 23, 2021·Clinics in Laboratory Medicine·Juliana Pereira Lopes GonçalvesKristina Schwamborn

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.