Frozen section diagnosis of pancreatic malignancy: a sensitive diagnostic technique

Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
H DoucasD P Berry

Abstract

Patients with potentially resectable pancreatic masses, without evidence of metastatic disease, require surgical exploration. We assessed the reliability of frozen section diagnosis of pancreatic malignancy. We analysed data from 120 patients who underwent pancreatic exploration, including frozen section assessment, over a period of 41 months. A total of 310 pancreatic biopsies were sent for frozen section analysis. The frozen section result concurred with the final histological diagnosis in 98.1% of biopsies. The false-negative rate was 1.9%, with the correct diagnosis being established on subsequent frozen section in half of these cases. Only 3 patients were not correctly diagnosed intra-operatively by frozen section. The majority of tumours identified were pancreatic ductal adenocarcinomas, but endocrine tumours and lymphoma were also detected. 15 (12.5%) patients required more than one set of biopsies in order to establish a diagnosis of malignancy. 19 (15.8%) patients had malignant disease outside the pancreas, making their tumours unsuitable for curative resection. Frozen section diagnosis is very reliable in the assessment of pancreatic masses and accurately differentiates between benign and malignant disease. More than ...Continue Reading

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Citations

Jun 26, 2009·Journal de chirurgie·K SlimP Valleur
Jul 14, 2012·World Journal of Gastroenterology : WJG·Mehdi OuaïssiBernard Sastre
Feb 22, 2012·Journal of Visceral Surgery·D ChatelainJ-M Regimbeau
Oct 8, 2008·Virchows Archiv : an International Journal of Pathology·Anne Couvelard, Alain Sauvanet
Mar 19, 2020·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Richard ZhengJordan M Winter
Nov 1, 2016·Case Reports in Pancreatic Cancer·Jillian W BonarotiJordan M Winter

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