Frozen section during partial nephrectomy: does it predict positive margins?

BJU International
Jennifer GordetskyJ I Epstein

Abstract

To investigate the clinical utility of frozen section (FS) analysis performed during partial nephrectomy (PN) and its influence on intra-operative management. We performed a retrospective analysis of consecutive PN cases from 2010 to 2013. We evaluated the concordance between the intra-operative FS diagnosis and the FS control diagnosis, a postoperative quality assurance measure performed on all FS diagnoses after formalin fixation of the tissue. We also evaluated the concordance between the intra-operative FS diagnosis and the final specimen margin. Operating reports were reviewed for change in intra-operative management for cases with a positive or atypia FS diagnosis, or if the mass was sent for FS. A total of 576 intra-operative FSs were performed in 351 cases to assess the PN tumour bed margin, 19 (5.4%) of which also had a mass sent for FS to assess the tumour type. The concordance rate between the FS diagnosis and the FS control diagnosis was 98.3%. There were 30 (8.5%) final positive specimen margins, of which four (13.3%) were classified as atypia, 17 (56.7%) as negative and nine (30%) as positive on FS diagnosis. Intra-operative management was influenced in six of nine cases with a positive FS diagnosis and in one of ...Continue Reading

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Citations

Nov 7, 2015·BJU International·Grant D Stewart, Grenville Oades
Jun 27, 2018·Journal of Endourology·Julien DagenaisJihad H Kaouk
Jan 26, 2018·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Patricio Garcia MarchiñenaGuillermo Gueglio
Dec 22, 2019·International Journal of Cancer. Journal International Du Cancer·Kanchustambham VijayalakshmiJames D Brooks
Feb 18, 2017·Current Urology Reports·Dean D LaganoskyViraj A Master
Nov 20, 2016·International Journal of Urology : Official Journal of the Japanese Urological Association·Hiroshi Miyamoto

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