PMID: 696824Sep 1, 1978Paper

Fructose-6-phosphate substrate cycling and hormonal regulation of gluconeogenesis in vivo

The American Journal of Physiology
M Chenoweth, A Dunn

Abstract

The possible role of the hepatic fructose-6-phosphate substrate cycle (phosphofructokinase, fructose-1,6-diphosphatase) in the rapid hormonal regulation of gluconeogenesis was investigated in vivo in fasted normal and adrenalectomized rats after administration of [3-3H, U-14C]- or [3-3H, 6-14C]glucose. The plasma glucose 3H/14C ratio was used as an index of substrate cycling because the amount of 3H loss from liver hexose phosphates is determined by the extent of cycling. PFK and FDPase activities limit 3H loss during gluconeogenesis and glycolysis, respectively. Glucagon-stimulated hepatic glucose production is always accompanied by increased substrate cycling, i.e., increased FDPase and PFK activities. The high PFK activity may be a secondary event due possibly to elevated cellular fructose-6-phosphate levels. Decreased substrate cycling, i.e., lowered FDPase activity, always accompanies the depressed hepatic glucose production that occurs during hyperglycemia. Glucagon has no effect on substrate cycling in adrenalectomized rats that are insensitive to the hormone. The in vivo experiments presented provide evidence, although indirect, that glucagon administration results in changes in the fructose-6-phosphate substrate cycle ...Continue Reading

References

Feb 24, 1976·Biochimica Et Biophysica Acta·T H Claus, S J Pilkis
Feb 1, 1976·Diabetes·T PozefskyJ D Tobin
Feb 1, 1976·Proceedings of the Society for Experimental Biology and Medicine·T M Chan, R A Freedland
Jan 1, 1976·Current Topics in Cellular Regulation·J Katz, R Rognstad
Nov 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·N M KneerH A Lardy
Oct 1, 1973·Biochemical and Biophysical Research Communications·D G ClarkJ Katz
Oct 1, 1973·Biochemical and Biophysical Research Communications·R RognstadJ Katz
Nov 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·R N ZahltenH A Lardy
Nov 1, 1969·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·M HollmannK F Weinges
Oct 11, 1967·Biochemical and Biophysical Research Communications·N FriedmannC R Park

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