Fructose amplifies counterregulatory responses to hypoglycemia in humans

Diabetes
Ilan GabrielyHarry Shamoon

Abstract

Glucokinase (GK) is required for cellular glucose sensing, although there is a paucity of data regarding its role in the counterregulatory response to hypoglycemia in humans. Because fructose has been shown to modulate GK activity, we examined the effects of an acute infusion of fructose on hypoglycemia counterregulation in seven lean nondiabetic subjects. Using stepped hypoglycemia clamp studies (5.0, 4.4, 3.9, and 3.3 mmol/l target plasma glucose steps, 50 min each), subjects were studied on two separate occasions, without (control) or with co-infusion of fructose (1.2 mg.kg(-1).min(-1)). Fructose induced a resetting of the glycemic thresholds for secretion of epinephrine (3.8 +/- 0.1 mmol/l) and glucagon (3.9 +/- 0.2 mmol/l) to higher plasma glucose concentrations (4.0 +/- 0.1 mmol/l [P = 0.006] and 4.1 +/- 0.1 mmol/l [P = 0.03], respectively). In addition, the magnitude of increase in epinephrine and glucagon concentrations was higher after administration of fructose (48 and 39%, respectively, P < 0.05 for both). The amplification of these hormonal responses was specific because plasma norepinephrine, growth hormone, and cortisol were comparable in both sets of studies. Endogenous glucose production, measured with [3-(3)H]g...Continue Reading

References

Sep 1, 1991·European Journal of Biochemistry·M DetheuxE Van Schaftingen
Nov 1, 1991·The Journal of Clinical Endocrinology and Metabolism·M R Davis, H Shamoon
Jan 1, 1989·The Journal of Clinical Endocrinology and Metabolism·M J SotskyH Shamoon
Feb 1, 1988·Diabetes/metabolism Reviews·R T FrizzellA D Cherrington
Sep 1, 1994·Diabetologia·E Van Schaftingen
Jul 1, 1994·Diabetes Care·P E CryerH Shamoon
Apr 1, 1994·The Journal of Clinical Investigation·W P BorgG I Shulman
Sep 30, 1993·The New England Journal of Medicine·UNKNOWN Diabetes Control and Complications Trial Research GroupC Siebert
May 8, 1999·The American Journal of Physiology·B E LevinV H Routh
May 9, 2000·Journal of Neurochemistry·I RonceroE Blázquez
Jul 25, 2000·Diabetes·R M LynchB E Levin
Sep 12, 2001·American Journal of Physiology. Endocrinology and Metabolism·C V MobbsX J Yang
Sep 25, 1959·Annals of the New York Academy of Sciences·R STEELE

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Citations

Jul 26, 2013·The New England Journal of Medicine·Philip E Cryer
Jun 17, 2006·Current Opinion in Clinical Nutrition and Metabolic Care·Kim-Anne Lê, Luc Tappy
Jan 4, 2007·Nephrology·Sachin S SoniAnuradha Raman
Feb 10, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Katia De AngelisMariana Morris
Feb 25, 2010·Endocrinology·Mayowa A OsundijiMark L Evans
Jul 2, 2009·The Journal of Clinical Endocrinology and Metabolism·James LeuIlan Gabriely
Mar 4, 2008·Diabetic Medicine : a Journal of the British Diabetic Association·R McCrimmon
Jul 18, 2006·Autonomic Neuroscience : Basic & Clinical·Vera FarahMariana Morris
May 4, 2016·The Journal of Clinical Investigation·Jason J WinnickAlan D Cherrington
Nov 17, 2017·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Eric Lontchi-YimagouMeredith Hawkins
Dec 29, 2016·American Journal of Physiology. Endocrinology and Metabolism·Zeenat A AsgharKelle H Moley
Aug 1, 2019·Archives of Endocrinology and Metabolism·Débora Lopes SoutoEliane Lopes Rosado
Feb 25, 2009·Molecular and Cellular Biochemistry·Mohammad M AbdullahMohammed H Moghadasian

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