Abstract
Glucokinase (GK) is required for cellular glucose sensing, although there is a paucity of data regarding its role in the counterregulatory response to hypoglycemia in humans. Because fructose has been shown to modulate GK activity, we examined the effects of an acute infusion of fructose on hypoglycemia counterregulation in seven lean nondiabetic subjects. Using stepped hypoglycemia clamp studies (5.0, 4.4, 3.9, and 3.3 mmol/l target plasma glucose steps, 50 min each), subjects were studied on two separate occasions, without (control) or with co-infusion of fructose (1.2 mg.kg(-1).min(-1)). Fructose induced a resetting of the glycemic thresholds for secretion of epinephrine (3.8 +/- 0.1 mmol/l) and glucagon (3.9 +/- 0.2 mmol/l) to higher plasma glucose concentrations (4.0 +/- 0.1 mmol/l [P = 0.006] and 4.1 +/- 0.1 mmol/l [P = 0.03], respectively). In addition, the magnitude of increase in epinephrine and glucagon concentrations was higher after administration of fructose (48 and 39%, respectively, P < 0.05 for both). The amplification of these hormonal responses was specific because plasma norepinephrine, growth hormone, and cortisol were comparable in both sets of studies. Endogenous glucose production, measured with [3-(3)H]g...Continue Reading
References
Jul 1, 1976·The Journal of Clinical Investigation·A J GarberD M Kipnis
Aug 15, 1992·The Biochemical Journal·A VandercammenE Van Schaftingen
Sep 1, 1991·European Journal of Biochemistry·M DetheuxE Van Schaftingen
Nov 1, 1991·The Journal of Clinical Endocrinology and Metabolism·M R Davis, H Shamoon
Jan 1, 1991·The American Journal of Physiology·A MitrakouJ Gerich
Jun 1, 1990·Diabetes·F M Matschinsky
Jan 1, 1989·Diabetes·D W BiggersR T Frizzell
Jan 1, 1989·The Journal of Clinical Endocrinology and Metabolism·M J SotskyH Shamoon
Jan 15, 1989·European Journal of Biochemistry·E Van Schaftingen
Feb 1, 1988·Diabetes/metabolism Reviews·R T FrizzellA D Cherrington
Aug 1, 1987·Diabetes·D T FinegoodM Vranic
Mar 1, 1987·The Journal of Clinical Investigation·N S SchwartzP E Cryer
Jun 1, 1983·Diabetes·J Kleinbaum, H Shamoon
Aug 1, 1995·The Biochemical Journal·L AgiusE Van Schaftingen
Sep 1, 1994·Diabetologia·E Van Schaftingen
Feb 1, 1995·Diabetes·W P BorgG I Shulman
Feb 1, 1995·The Journal of Clinical Investigation·J H HwangG I Shulman
Jul 1, 1994·Diabetes Care·P E CryerH Shamoon
Nov 1, 1994·The American Journal of Physiology·P TounianL Tappy
Dec 1, 1994·The American Journal of Medicine·M DavisH Shamoon
Apr 1, 1994·The Journal of Clinical Investigation·W P BorgG I Shulman
Nov 1, 1993·Diabetologia·F M Matschinsky
Dec 15, 1993·The Biochemical Journal·L Agius, M Peak
Sep 30, 1993·The New England Journal of Medicine·UNKNOWN Diabetes Control and Complications Trial Research GroupC Siebert
Jan 15, 1997·The Journal of Clinical Investigation·M A BorgG I Shulman
Jun 27, 1998·Journal of Pediatric Endocrinology & Metabolism : JPEM·G B Bolli
May 8, 1999·The American Journal of Physiology·B E LevinV H Routh
May 9, 2000·Journal of Neurochemistry·I RonceroE Blázquez
Jul 25, 2000·Diabetes·R M LynchB E Levin
Feb 15, 2001·European Journal of Endocrinology·E GuenatL Tappy
May 26, 2001·Diabetes·K F PetersenG I Shulman
Sep 12, 2001·American Journal of Physiology. Endocrinology and Metabolism·C V MobbsX J Yang
Sep 25, 1959·Annals of the New York Academy of Sciences·R STEELE
Citations
Jul 26, 2013·The New England Journal of Medicine·Philip E Cryer
May 1, 2004·Journal of Medicinal Food·Noori S Al-Waili
Dec 18, 2013·Journal of Medicinal Food·Noori Al-WailiThia Al-Waili
Jun 17, 2006·Current Opinion in Clinical Nutrition and Metabolic Care·Kim-Anne Lê, Luc Tappy
Jan 4, 2007·Nephrology·Sachin S SoniAnuradha Raman
Feb 10, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Katia De AngelisMariana Morris
Feb 25, 2010·Endocrinology·Mayowa A OsundijiMark L Evans
Jul 2, 2009·The Journal of Clinical Endocrinology and Metabolism·James LeuIlan Gabriely
Mar 4, 2008·Diabetic Medicine : a Journal of the British Diabetic Association·R McCrimmon
Jul 18, 2006·Autonomic Neuroscience : Basic & Clinical·Vera FarahMariana Morris
Jan 5, 2011·Diabetes·Philip E Cryer
Mar 1, 2005·Diabetes·Ilan Gabriely, Harry Shamoon
May 4, 2016·The Journal of Clinical Investigation·Jason J WinnickAlan D Cherrington
Nov 17, 2017·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Eric Lontchi-YimagouMeredith Hawkins
Dec 29, 2016·American Journal of Physiology. Endocrinology and Metabolism·Zeenat A AsgharKelle H Moley
Aug 1, 2019·Archives of Endocrinology and Metabolism·Débora Lopes SoutoEliane Lopes Rosado
Feb 25, 2009·Molecular and Cellular Biochemistry·Mohammad M AbdullahMohammed H Moghadasian