PMID: 9450508Feb 5, 1998Paper

Fructose perfusion in rat mesenteric arteries impairs endothelium-dependent vasodilation

Life Sciences
J M RicheyR C Webb

Abstract

We demonstrated that the fructose-induced hypertensive rat, representative of the principal metabolic abnormalities found in a majority of hypertensive patients, i.e. hypertriglyceridemia, hyperinsulinemia and insulin resistance (Syndrome X), is associated with an impaired response to endothelium-dependent vasodilators and that fructose may directly contribute to this impairment. Twelve male Wistar rats were divided into two groups, one given 10% fructose (n=6); the other no fructose (n=6) for 40 days in the drinking water. Systolic blood pressure was measured via the tail cuff method. Perfusion pressure responses to acetylcholine, were measured in the isolated perfused mesenteric vascular bed. Constrictor or dilator responses were measured as increases or decreases, respectively, of the perfusion pressure at a constant flow (4 ml/min). Fructose-fed rats had significantly higher blood pressure, insulin and triglyceride levels than control animals. In phenylephrine constricted beds, the endothelium-dependent dilatation to acetylcholine (0.001 to 1 micromol) was attenuated in the fructose-fed group compared to control animals. Whether this abnormality results from the syndromes (hyperinsulinemia, hypertension and hypertriglycerid...Continue Reading

References

Feb 1, 1992·Hypertension·T F LüscherZ H Yang
Jul 1, 1990·The Journal of Clinical Investigation·M A CreagerV J Dzau
Mar 1, 1990·The Journal of Clinical Investigation·B TesfamariamR A Cohen
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May 1, 1993·Circulation·V Gurewich

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Citations

Nov 15, 2008·The Journal of Pharmacology and Experimental Therapeutics·Chun Xia ZhaoDao Wen Wang
Jul 13, 2012·Canadian Journal of Physiology and Pharmacology·Niraj M BhattSarita Gupta
Aug 18, 2020·Life Sciences·Deborah de Farias LelisMarcelo Perim Baldo

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