PMID: 15362482Sep 15, 2004Paper

Fructose transport and metabolism in adipose tissue of Zucker rats: diminished GLUT5 activity during obesity and insulin resistance

Molecular and Cellular Biochemistry
Gary J LitherlandH S Hundal

Abstract

Fructose is a major dietary sugar, which is elevated in the serum of diabetic humans, and is associated with metabolic syndromes important in the pathogenesis of diabetic complications. The facilitative fructose transporter, GLUT5, is expressed in insulin-sensitive tissues (skeletal muscle and adipocytes) of humans and rodents, where it mediates the uptake of substantial quantities of dietary fructose, but little is known about its regulation. We found that GLUT5 abundance and activity were compromised severely during obesity and insulin resistance in Zucker rat adipocytes. Adipocytes from young obese (fa/fa), highly insulin-responsive Zucker rats contained considerably more plasma membrane GLUT5 than those from their lean counterparts (1.8-fold per microgram membrane protein), and consequently exhibited higher fructose transport (fivefold) and metabolism (threefold) rates. Lactate production was the preferred route for fructose metabolism in these cells. As the rats aged and become more obese and insulin-resistant, adipocyte GLUT5 surface density (12-fold) and fructose transport (10-fold) and utilisation rates (threefold) fell markedly. The GLUT5 loss was more dramatic in adipocytes from obese animals, which developed a more m...Continue Reading

Citations

Jul 23, 2015·Journal of Nutrition and Metabolism·Astrid Kolderup, Birger Svihus
Jun 17, 2006·Current Opinion in Clinical Nutrition and Metabolic Care·Kim-Anne Lê, Luc Tappy
Jan 21, 2010·Physiological Reviews·Luc Tappy, Kim-Anne Lê
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Aug 8, 2014·Nutrients·Maren R Laughlin
Feb 23, 2018·World Journal of Gastroenterology : WJG·Flavia MerigoGiacomo Carlo Sturniolo
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Feb 7, 2013·Clinical Science·Juan Pablo FariñaJuan José Gagliardino
Jul 30, 2014·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Cihan CitilYusuf Ozkan
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Jun 12, 2019·International Journal of Molecular Sciences·Adrián Hernández-DíazcouderFausto Sánchez-Muñoz
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Nov 7, 2012·British Journal of Pharmacology·Jianghai LiuLingyun Wu
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Aug 18, 2020·Life Sciences·Deborah de Farias LelisMarcelo Perim Baldo
Feb 23, 2005·Nutrition & Metabolism·Heather BascianoKhosrow Adeli
Nov 6, 2009·Biochemical and Biophysical Research Communications·Clare StrettonHarinder S Hundal

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