Fructus Corni suppresses hepatic gluconeogenesis related gene transcription, enhances glucose responsiveness of pancreatic beta-cells, and prevents toxin induced beta-cell death

Journal of Ethnopharmacology
Chien-Chih ChenHui-Kang Liu

Abstract

Fructus Corni, the fruits of Cornus officinalis Sieb. et Zucc., is one important ingredient in Quei Fu Di Huang Wan, a Chinese herbal mixture. In the present study, additional anti-diabetic actions of Fructus Corni on transcriptional regulation of hepatic gluconeogenesis or beta-cell functions were investigated. Insulin mimetic action of Fructus Corni on dexamethasone and 8-bromo-cAMP induced phosphoenolpyruvate carboxykinase (PEPCK) expression in H4IIE cells was investigated. Besides, BRIN-BD11 cells were used to evaluate both insulinotropic and beta-cell protective effect of Fructus Corni. Firstly, both methanol extract (CO-W-M) and fraction (CO-W-M2) had potent insulin mimic activity on PEPCK expression. Secondly, possibility of both loganin and ursolic acid as the responsible compounds was excluded. Moreover, indication of the existence of phenolic compounds in CO-W-M2 was noticed. In the presence of CO-W-M2, not only was the viability of BRIN-BD11 cells treated with alloxan, streptozotcin, or cytokine mix all significantly increased but also glucose-stimulated insulin secretion was potentiated. The ability of CO-W-M2 to reduce gene expression for hepatic gluconeogenesis, to protect beta-cell against toxic challenge, and to...Continue Reading

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Citations

Apr 10, 2013·Asian Pacific Journal of Tropical Biomedicine·D K PatelS Hemalatha
Dec 15, 2012·World Journal of Gastroenterology : WJG·Yi-Shin HsuHui-Kang Liu
Jun 6, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Zhijun WangPatrick Chan
Apr 23, 2011·Bioscience, Biotechnology, and Biochemistry·Shun Zong SongGuang Hai Yan
Jul 12, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Chung-Yu HuangFeng-Lin Hsu
Aug 7, 2012·Expert Opinion on Investigational Drugs·Tian-Tian Zhang, Jian-Guo Jiang
Jan 26, 2010·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Y-C JuanH-K Liu
Mar 15, 2016·Biochemical and Biophysical Research Communications·Liangchang LiGuanghai Yan
Mar 31, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Hai-Ming ZhangRui Chen
Mar 6, 2009·Phytochemistry·Hui-Kang LiuLie-Chwen Lin
Jul 19, 2012·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Lin WangLiang-neng Wu
Sep 14, 2018·Frontiers in Pharmacology·Monika E Czerwińska, Matthias F Melzig
Dec 28, 2019·International Journal of Molecular Sciences·Gideon Gatluak KangAbishek Bommannan Santhakumar
Aug 8, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jie SunYan Yang
Nov 16, 2017·Journal of Natural Products·Xian-Sheng YeJie-Kun Xu

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