Fruit and vegetable intake and liver cancer risk: a meta-analysis of prospective cohort studies

Food & Function
Xiao-Fei GuoDuo Li

Abstract

The associations of vegetable and fruit intake with liver cancer risk have been inconsistent based on epidemiological studies. The present study aimed to quantitatively evaluate these associations with prospective cohort studies. A systematic literature search was performed with PubMed and Scopus databases up to June 2019. Multivariate-adjusted relative risks (RRs) with a corresponding 95% confidence interval (CI) for the highest versus lowest category were pooled by using a random-effects model. Pre-specified subgroup and univariate meta-regression analyses were performed to identify the sources of heterogeneity. Dose-response analysis was conducted by using the variance weighted least squares regression model. Nine independent prospective cohort studies with 1703 liver cancer events and 1 326 176 participants were included for data synthesis. The summary estimates showed that higher vegetable intake was associated with a 39% (95%CI: 0.50, 0.75) reduction in liver cancer risk, with no significant between-study heterogeneity (P = 0.057). Dose-response analysis indicated that the risk of liver cancer was reduced by 4% (95%CI: 0.97, 0.95; P for trend <0.001) with a 100 gram per day increment of vegetable intake. Subgroup analysis...Continue Reading

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Citations

Aug 26, 2020·Nutritional Neuroscience·Sanaz SoltaniAhmad Esmaillzadeh
Nov 10, 2020·Frontiers in Oncology·Chunye ZhangAaron C Ericsson
Jan 30, 2021·Food Research International·Guilherme Ribeiro RomualdoLuís Fernando Barbisan
Mar 14, 2021·Seminars in Cancer Biology·Violet Kayamba
May 1, 2021·Nutrients·Andrea MegaAnnarosa Floreani
Sep 6, 2021·International Journal of Clinical Practice·Fatemeh SheikhhosseinSakineh Shab-Bidar

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Software Mentioned

Scopus
STATA

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