PMID: 2508089Oct 1, 1989Paper

Fruit flies with additional expression of the elongation factor EF-1 alpha live longer

Proceedings of the National Academy of Sciences of the United States of America
J C ShepherdW J Gehring

Abstract

In Drosophila melanogaster, the decrease in protein synthesis that accompanies aging is preceded by a decrease in elongation factor EF-1 alpha protein and mRNA. Here we show that Drosophila transformed with a P-element vector containing an EF-1 alpha gene under control of hsp70 regulatory sequences have a longer life-span than control flies.

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