PMID: 8939775Dec 1, 1996Paper

FTIR microspectroscopic analysis of human osteonal bone

Calcified Tissue International
E P PaschalisA L Boskey

Abstract

Fourier Transform Infrared Microspectroscopy (FTIRM) has been used to study the changes in mineral and matrix content and composition in replicate biopsies of nonosteoporotic human osteonal bone. Spectral maps in four orthogonal directions (in 10 microm steps) from the centers towards the peripheries of individual osteons were obtained from iliac crest biopsies of two necropsy cases. Mineral to matrix ratios, calculated from the ratio of integrated areas of the phosphate nu1,nu3 band at 900-1200 cm-1 to the amide I band at 1585-1725 cm-1, increased from the center to the periphery of the osteon. The total carbonate (based on the nu2 band at approximately 850-900 cm-1) to phosphate nu1,nu3 ratio decreased as the mineral to matrix ratio increased. Analysis of the nu2 CO32- band with a combination of second-derivative spectroscopy and curve fitting revealed a decrease in "labile" carbonate, a slight decrease in Type A and a slight increase in Type B carbonate from the center to the periphery of the osteon. Similar analysis of the components of the nu1,nu3 phosphate band with a combination of second-derivative spectroscopy and curve fitting revealed the presence of 11 major underlying moieties. These components were assigned by com...Continue Reading

References

Jun 1, 1975·Journal of Dental Research·A S PosnerF Betts
Jul 1, 1992·Calcified Tissue International·N L PleshkoR Mendelsohn
Sep 1, 1992·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·N L PleshkoR Mendelsohn
Jul 1, 1990·Journal of Inorganic Biochemistry·M A WaltersK A Konsker
Nov 1, 1990·Bone and Mineral·E BonucciB Imbimbo
Sep 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J T NinomiyaK G Mann
Jan 1, 1989·Calcified Tissue International·R MendelsohnA Boskey
Jul 7, 1983·The New England Journal of Medicine·L G Raisz, B E Kream
Mar 1, 1995·Journal of Biomedical Materials Research·A el-GhannamI M Shapiro
May 1, 1995·Bone·C ReyM J Glimcher
Mar 24, 1995·Science·B R ConstantzD I Rosenthal
Aug 1, 1994·Biomaterials·I RehmanR Smith
May 1, 1994·Calcified Tissue International·G R SauerR E Wuthier
Jan 1, 1993·Calcified Tissue International·M Grynpas

❮ Previous
Next ❯

Citations

Dec 3, 1998·Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie·S BohicG Daculsi
Apr 24, 2003·European Journal of Biochemistry·Eva HamadeBernard Roux
Oct 23, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S BohicD Heymann
Sep 22, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M C Monier-FaugereH H Malluche
Feb 23, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A L BoskeyR D Blank
Oct 5, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·E P PaschalisM Yamauchi
Sep 14, 2006·Calcified Tissue International·G A P RendersT M G J van Eijden
Aug 24, 2010·Calcified Tissue International·Eve DonnellyMarjolein C H van der Meulen
Sep 23, 2014·Current Osteoporosis Reports·S GamsjaegerE P Paschalis
Jul 20, 2014·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·B HofstetterE P Paschalis
Sep 5, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A L BoskeyR S Weinstein
Apr 14, 2009·Calcified Tissue International·Zhen-Jiang ChengFu-Zhai Cui
Jan 22, 2010·Journal of Bone and Mineral Metabolism·Delphine FarlayGeorges Boivin
Oct 7, 2010·Journal of Dental Research·A L Boskey, R Coleman
Mar 5, 2013·PloS One·Hélène FolletRoland Chapurlat
Oct 9, 2013·Nature Reviews. Nephrology·Hartmut H MallucheDavid Pienkowski
Sep 1, 2012·Journal of Biological Physics·Nikolaos KourkoumelisMargaret Tzaphlidou
May 9, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H Ou-YangR Mendelsohn
Dec 20, 2005·Calcified Tissue International·B BusaS Judex
Jun 7, 2007·Calcified Tissue International·Ayorinde AwonusiMary M J Tecklenburg
Mar 5, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M E RuppelD B Burr
Apr 3, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·E P Paschalis
Feb 25, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·D ChappardM Audran
Dec 12, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S GamsjaegerE P Paschalis
Dec 12, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Y BalaG Boivin
Jun 18, 2009·Urological Research·Ted Hueih-Shing HsuMei-Jane Li
Oct 19, 2005·Archives of Dermatological Research·Ming-Tzen LiuShan-Yang Lin
Jul 3, 2010·Biomechanics and Modeling in Mechanobiology·J Martínez-ReinaJ M García-Aznar
Aug 6, 2013·The Journal of Endocrinology·Guillaume MabilleauDaniel Chappard
Feb 3, 2015·Experimental Gerontology·Marta AidoBettina M Willie
Dec 22, 2012·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Chunju GuKalpana S Katti
May 3, 2012·Journal of Structural Biology·Oscar Cambra-MooArmando González Martín
Apr 14, 2012·Journal of the Mechanical Behavior of Biomedical Materials·Anna FaingoldH Daniel Wagner

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.