FTIR spectral signature of anticancer drugs. Can drug mode of action be identified?

Biochimica Et Biophysica Acta
Alix MignoletErik Goormaghtigh

Abstract

Infrared spectroscopy has brought invaluable information about proteins and about the mechanism of action of enzymes. These achievements are difficult to transpose to living organisms as all biological molecules absorb in the mid infrared, with usually a high degree of overlap. Deciphering the contribution of each enzyme is therefore almost impossible. On the other hand, small changes in the infrared spectra of cells induced by environmental conditions or drugs may provide an accurate signature of the metabolic shift experienced by the cell as a response to a change in the growth medium. The present paper aims at reviewing the contribution of infrared spectroscopy to the description of small chemical changes that occur in cells when they are exposed to a drug. In particular, this review will focus on cancer cells and anti-cancer drugs. Results accumulated so far tend to demonstrate that infrared spectroscopy could be a very accurate descriptor of the mode of action of anticancer drugs. If confirmed, such a segmentation of potential drugs according to their "mode of action" will be invaluable for the discovery of new therapeutic molecules. This article is part of a Special Issue entitled: Physiological Enzymology and Protein Fun...Continue Reading

References

Oct 13, 1992·Biochemistry·G M MacDonald, B A Barry
Jan 1, 1991·Journal of General Microbiology·D HelmD Naumann
Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·P T WongB Rigas
Nov 4, 1991·Biochimica Et Biophysica Acta·R BuchetA Martonosi
May 2, 1991·Nature·D NaumannH Labischinski
Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·B RigasP T Wong
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·K J RothschildJ Herzfeld
Nov 6, 1989·Biochimica Et Biophysica Acta·E GoormaghtighJ M Ruysschaert
Apr 5, 1988·Biochemistry·K J RothschildJ L Spudich
Jun 11, 1980·Nucleic Acids Research·W Pohle, H Fritzsche
Nov 29, 1996·The Journal of Biological Chemistry·A BarthW Mäntele
Jul 7, 1999·Biochimica Et Biophysica Acta·E GoormaghtighJ M Ruysschaert
Dec 22, 1999·Progress in Biophysics and Molecular Biology·J L Arrondo, F M Goñi
Jul 5, 2001·Proceedings of the National Academy of Sciences of the United States of America·C AllinK Gerwert
Oct 9, 2001·European Journal of Biochemistry·N BaeyensE Goormaghtigh
Apr 16, 2002·European Journal of Biochemistry·Anthoula GaigneauxErik Goormaghtigh
May 16, 2002·Biopolymers·Max DiemAnthony Pacifico
Dec 21, 2002·Differentiation; Research in Biological Diversity·Mina J BissellOle W Petersen

❮ Previous
Next ❯

Citations

Mar 14, 2019·The Analyst·Ali AltharawiK L Andrew Chan
Jul 10, 2019·Scientific Reports·Mohamed H M AliErik Goormaghtigh
Mar 3, 2020·Expert Opinion on Drug Delivery·Yijie SongNing Zhang
Oct 28, 2020·Biomolecules·Valerie SamouillanVicenta Llorente Cortes
Oct 8, 2018·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Sumanta KarKalpana S Katti
May 4, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Piman PocasapNatthida Weerapreeyakul
Jul 3, 2021·Biophysical Journal·Luis Alberto Esteves Batista de CarvalhoMaria Paula Matos Marques
Jul 25, 2019·The Journal of Physical Chemistry. B·Maria Paula M MarquesLuís A E Batista de Carvalho

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

© 2021 Meta ULC. All rights reserved