FTO genotype, dietary protein intake, and body weight in a multiethnic population of young adults: a cross-sectional study

Genes & Nutrition
David C MerrittAhmed El-Sohemy

Abstract

Variation in the fat mass and obesity-associated gene (FTO) has been associated with susceptibility to obesity, but the association appears to be modified by diet. We investigated whether dietary protein intake modifies the association between FTO variant rs1558902 and body mass index (BMI) and waist circumference in young adults (n = 1491) from the cross-sectional Toronto Nutrigenomics and Health Study. Lifestyle, genetic, anthropometric, and biochemical data were collected and diet was assessed using a Toronto-modified Willett Food Frequency Questionnaire. General linear models stratified by ethnicity and adjusted for age, sex, and total energy intake were used to examine the association between FTO genotypes and measures of body weight, and whether protein intake modified any of the associations. East Asians who were homozygous for the rs1558902 risk allele (A) had a greater BMI (p = 0.004) and waist circumference (p = 0.03) than T allele carriers. This association was not observed in individuals of Caucasian or South Asian ancestry. Among East Asians, a significant FTO-protein interaction was observed for BMI (p = 0.01) and waist circumference (p = 0.007). Those with low protein intake (≤ 18% total energy intake) who were h...Continue Reading

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Citations

Apr 2, 2019·The British Journal of Nutrition·Firoozeh Hosseini-EsfahaniFereidoun Azizi
Aug 5, 2020·International Journal of Food Sciences and Nutrition·Kubra Isgin-AticiZehra Buyuktuncer
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Mar 7, 2019·Frontiers in Nutrition·Nanci S GuestAhmed El-Sohemy
Sep 2, 2018·BMC Medical Genetics·Anas SabarnehAbdelmajeed Nasereddin
Feb 18, 2021·International Journal of Legal Medicine·Sohee ChoHwan Young Lee
Mar 25, 2021·The Journal of Nutrition·Tara ZeitounAhmed El-Sohemy
May 1, 2021·International Journal of Molecular Sciences·Michal VrablikJaroslav A Hubacek
May 10, 2021·Molecular Genetics and Genomics : MGG·Sobia RanaAdil Anwar Bhatti
Apr 23, 2021·Current Opinion in Clinical Nutrition and Metabolic Care·Bibiana Garcia-Bailo, Ahmed El-Sohemy

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