FTY720 treatment of kidney transplant patients: a differential effect on B cells, naïve T cells, memory T cells and NK cells

Transplant Immunology
Leonard M B VaessenWillem Weimar

Abstract

FTY720 alters lymphocyte recirculation and homing by interfering with S1P receptors on lymphocytes, possibly in combination with chemokine receptors, and induces a decrease in PBL counts. In fresh, whole blood samples of 14 kidney transplant patients, we analyzed by flow cytometry the effect of FTY on the number of NK cells, monocytes, naïve (CCR7+) T cells, memory (CCR5+) T cells and B cells. Patients treated with 0.5, 2.5 or 5mg FTY/day showed a strong decrease in T and B cell numbers. NK cells and monocytes were not affected. FTY reduced primarily naïve T cells. From the memory T cells (CCR5+), predominantly CD8 cells, 40-60% remained in the circulation. The majority of the CCR7+ cells disappeared from the circulation within 3-6h, while a further reduction was achieved later. The more slowly decrease in naïve CCR7+ T cell numbers was also observed in the group treated with 0.25mg FTY/day. Elispot assays revealed no IL-4 producing cells and a low frequency of IFN-gamma producing cells. We suggest that both CCR7 dependent and independent mechanisms are involved in the depletion of T cells from peripheral blood.

References

Oct 9, 1998·American Journal of Reproductive Immunology : AJRI·N PorakishviliT Lund
Jul 31, 1999·Immunopharmacology·Z J LuoM Miyasaka
Apr 27, 2000·Current Opinion in Immunology·J J Campbell, E C Butcher
May 23, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·D D PinschewerR M Zinkernagel
May 23, 2000·European Journal of Immunology·H YagiT Itoh
Dec 19, 2001·The Journal of Experimental Medicine·G HenningR Förster
Mar 26, 2002·Journal of the American Society of Nephrology : JASN·Klemens BuddeHans H Neumayer
Aug 17, 2002·Current Opinion in Immunology·Tarek el-SawyRobert L Fairchild
Mar 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jenny H XieHugh Rosen
May 3, 2003·Annals of the New York Academy of Sciences·Gerd MüllerMartin Lipp
Jun 20, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Klemens BuddeHans-Hellmut Neumayer
Feb 10, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Torsten BöhlerKlemens Budde
Mar 6, 2004·Seminars in Immunology·Wolfgang Weninger, Ulrich H von Andrian
Mar 23, 2004·Annual Review of Immunology·Federica SallustoAntonio Lanzavecchia
Apr 21, 2004·The Journal of Experimental Medicine·M Lucila ScimoneWolfgang Weninger
May 22, 2004·International Archives of Allergy and Immunology·Toshiyuki TanakaMasayuki Miyasaka
Jun 16, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Volker BrinkmannTimothy Hla
Nov 1, 2005·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Nicolle H R LitjensMichiel G H Betjes

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Citations

Oct 8, 2009·The Journal of Experimental Medicine·Craig N JenneJerold Chun
Jul 27, 2011·Current Neurology and Neuroscience Reports·Matthias MehlingTobias Derfuss
Nov 13, 2007·International Immunopharmacology·Léa Bueno Lucas da SilvaValquiria Bueno
Mar 13, 2014·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Yusei MiyazakiSeiji Kikuchi
Jun 2, 2016·Expert Opinion on Drug Metabolism & Toxicology·Pierre-Eric JuifJasper Dingemanse
Feb 15, 2014·Multiple Sclerosis : Clinical and Laboratory Research·Masakazu NakamuraTakashi Yamamura
Nov 29, 2008·Seminars in Cancer Biology·Carsten Krieg, Onur Boyman
Dec 15, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Annabelle DrouillardThierry Walzer
Sep 22, 2017·International Journal of Molecular Sciences·Philip SmithPeter Gergely
May 31, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Trina A JohnsonJack P Antel
Mar 10, 2011·Annals of Neurology·Matthias MehlingChristoph Hess
Apr 28, 2016·European Journal of Immunology·Tadepally LakshmikanthJulius G Juarez
Dec 14, 2018·Frontiers in Immunology·Maxi KaufmannKatja Akgün
Jul 11, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Svenja C SchwichtenbergCarmen Infante-Duarte

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