Fucoidan-coated coral-like Pt nanoparticles for computed tomography-guided highly enhanced synergistic anticancer effect against drug-resistant breast cancer cells

Nanoscale
Seounghun KangDal-Hee Min

Abstract

Chemotherapy, the most commonly applied cancer treatment, often causes unexpected failure due to multidrug resistance (MDR). To overcome MDR, we have designed a platform to realize a combinational synergistic effect of a natural bioactive product (fucoidan), anticancer small compound (doxorubicin), and photothermal nanocarrier (Pt nanoparticle) to treat drug-resistant breast cancer cells. Especially, fucoidan, a sulfated, polysaccharide-structured, therapeutic biopolymer, has been recently recognized as a potential anticancer compound; however, its cancer-inhibiting efficacy has been regarded as low owing to its insufficient level in serum following its conventional oral ingestion. To enhance its potency, fucoidan was applied as a biocompatible surfactant and surface-coating biopolymer in nanocarrier synthesis to manufacture coral-like, fucoidan-coated Pt nanoparticles with a rough surface morphology by a one-pot method. As a result, the biological-thermo-chemo trimodal combination treatment showed excellent therapeutic efficiency against the MDR breast cancer cell MCF-7 ADR both in vitro and in vivo, and the computed tomography contrast effect was also confirmed from the constituent element Pt. Beyond universal application in ...Continue Reading

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Citations

May 2, 2020·Marine Drugs·María Elena ReyesPriscilla Brebi
Oct 23, 2020·International Journal of Biological Macromolecules·Kun-Ying LuEr-Yuan Chuang
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·N González-BallesterosM Lastra-Valdor
Aug 18, 2021·Food Research International·Yuezhen OuyangChao Zhao

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Methods Mentioned

BETA
irradiate
pull down
transmission electron microscopy
surface plasmon resonance
fluorescence microscopy
fluorescence imaging

Software Mentioned

ChemDoc
Metamorph

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