Fucoidan film safely inhibits surgical adhesions in a rat model

The Journal of Surgical Research
Johanne D CashmanChristopher M K Springate

Abstract

The purpose of this study was to evaluate the in vivo efficacy of 13 compounds and to further characterize the load limiting and potential toxicity of the most efficacious compound. The cascade of biochemical and molecular events that results in the formation of postsurgical adhesions provides numerous theoretical opportunities for prophylactic intervention. Candidate agents were loaded into sodium hyaluronate (HA) films and administered to male Sprague-Dawley rats using a cecal-sidewall model of surgical adhesions. An adhesion score was obtained for each rat based on the strength and extent of the adhesions. The most efficacious agent, fucoidan, was further evaluated in a load-limiting study with a concentration range of 0.0033 to 33% w/w per film. The potential toxicity of fucoidan was evaluated in a separate study by comparison of hematology findings, blood chemistry, urinalysis, and incision thickness from rats administered control films or 33% w/w fucoidan films 1 to 4 d prior to sacrifice. Fucoidan loaded films reduced adhesion scores by approximately 90% compared with control films (P<0.05). A total of 50% to 100% of animals were adhesion free at fucoidan film loadings of 0.33% to 33% w/w compared with all control film a...Continue Reading

References

Nov 1, 1985·Chest·L B Jaques
May 1, 1995·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·E K LeGrandG S Dizerega
Aug 1, 1995·The British Journal of Surgery·M Snoj
Feb 4, 1998·Journal of the American College of Surgeons·N F RayS Perry
Apr 12, 2000·The British Journal of Surgery·A A Van Der KrabbenH Van Goor
Sep 27, 2000·Diseases of the Colon and Rectum·M G ColemanB J Moran
Oct 26, 2000·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·T N ZvyagintsevaL A Elyakova
Jan 11, 2001·Thrombosis Research·F Haroun-BouhedjaC Boisson-Vidal
Dec 1, 2001·Human Reproduction Update·G S diZerega, J D Campeau
Apr 2, 2002·The Journal of Surgical Research·Hedef OzgünSerhan Sakarya
Sep 6, 2003·Cancer Cell·James B BrugarolasWilliam G Kaelin
Nov 18, 2003·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·A ImaiTeruhiko Tamaya
Apr 21, 2004·Obstetrical & Gynecological Survey·Dania Al-Jaroudi, Togas Tulandi
Aug 19, 2004·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·J CashmanJ K Jackson
Apr 16, 2005·Fertility and Sterility·Yanchun LiuGlenn D Prestwich
Apr 20, 2005·The Journal of Surgical Research·Nurullah BulbullerNecip Ilhan
Aug 2, 2005·Obstetrics and Gynecology·Deirdre J LyellKay Daniels
Jan 1, 1996·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·T J KrauseR D McKinnon
Dec 19, 2006·Fertility and Sterility·Umit KayaEsra Kuscu
Feb 7, 2007·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·Hasan Fehmi KucukHuseyin Akyol
Jul 7, 2007·Fertility and Sterility·UNKNOWN Practice Committee of the American Society for Reproductive Medicine, UNKNOWN Society of Reproductive Surgeons
Oct 27, 2007·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·J B C van der Wal, J Jeekel
Jun 11, 2008·BJU International·Orietta DalpiazHannes Strasser

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Citations

Nov 11, 2011·Marine Drugs·Janet Helen Fitton
Mar 4, 2014·Veterinary Medicine International·Juliana de Moura AlonsoCarlos Alberto Hussni
Aug 11, 2015·Current Problems in Surgery·Robel T BeyeneAdrian Barbul
Jan 26, 2013·Biochemical and Biophysical Research Communications·Tae Hee KimWon Seok Yang
Jun 15, 2016·International Journal of Molecular Sciences·Kadir OzaltinPetr Sáha
Jul 12, 2020·Materials·Heekyung ParkDonghyun Lee
May 21, 2013·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Daisuke NiwaShinji Takeoka

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