Fucoidan inhibits LPS-induced acute lung injury in mice through regulating GSK-3β-Nrf2 signaling pathway

Archives of Pharmacal Research
De-Zhang ZhuAi-Jie Liu

Abstract

The purpose of this study was to investigate the protective effects of fucoidan on Lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice. The mice were divided into the control, LPS, and LPS + fucoidan (20, 40, or 80 mg/kg) groups. LPS was given by intracheal instillation and fucoidan was given 1 h before LPS treatment. Myeloperoxidase (MPO) activity, malondialdehyde (MDA), superoxide dismutase (SOD), reactive oxygen species (ROS), glutathione (GSH) contents, and inflammatory cytokine production were detected. The results showed that LPS-induced TNF-α, IL-1β, and IL-6 production, lung wet/dry (W/D) ratio, ROS, MDA content, and MPO activity were suppressed by fucoidan. The levels of SOD and GSH were increased by fucoidan. Meanwhile, LPS-induced nuclear factor kappa-B (NF-κB) activation was dose-dependently attenuated by fucoidan. Furthermore, fucoidan increased the expression of nuclear factor erythroid-2 related factor 2 (Nrf2), Glycogen synthase kinase3β (GSK-3β), and heme oxygenase (HO-1). In vitro, the results demonstrated that fucoidan or GSK-3β inhibitor significantly inhibited LPS-induced TNF-α production in A549 cells. And the inhibition of fucoidan on TNF-α production was blocked by Nrf2 siRNA. This study sho...Continue Reading

References

Jul 1, 1997·American Journal of Respiratory Cell and Molecular Biology·T S Blackwell, J W Christman
Jan 7, 1999·The European Respiratory Journal·R Ruffmann
Jan 24, 2002·American Journal of Respiratory Cell and Molecular Biology·Hye-Youn ChoSteven R Kleeberger
Jan 27, 2004·The Journal of Pathology·Madhav Bhatia, Shabbir Moochhala
Oct 12, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Mauricio RojasKenneth L Brigham
Jan 13, 2005·Critical Care Medicine·Polly E ParsonsUNKNOWN NHLBI Acute Respiratory Distress Syndrome Clinical Trials Network
Jun 25, 2005·American Journal of Respiratory and Critical Care Medicine·Ellen L BurnhamMarc Moss
Sep 22, 2005·Nature Reviews. Immunology·Michael Karin, Florian R Greten
Oct 26, 2005·Nature Medicine·Dianhua JiangPaul W Noble
Feb 3, 2009·The Journal of Biological Chemistry·Truyen NguyenCecil B Pickett
May 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Narsa M ReddySekhar P Reddy
Oct 22, 2009·Clinical and Experimental Pharmacology & Physiology·Yan-Qiu CuiXiao-Min Wang
Jun 7, 2011·International Immunopharmacology·Ying LiuPei-Bo Li
Dec 12, 2012·Carbohydrate Polymers·Seung-Hong LeeYou-Jin Jeon
Oct 28, 2014·International Journal of Molecular Sciences·Min XiaoFu-Qiang Wen
Dec 18, 2016·International Immunopharmacology·Jisang ParkYong-Suk Jang

❮ Previous
Next ❯

Citations

Dec 31, 2020·Marine Drugs·J Helen FittonDamien N Stringer
Feb 18, 2021·Carbohydrate Polymers·Carlos Vaamonde-GarcíaRosa Meijide-Faílde
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ming-Yang TsaiGeng-Ruei Chang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.