Fucoidan isolated from Ascophyllum nodosum alleviates gut microbiota dysbiosis and colonic inflammation in antibiotic-treated mice.

Food & Function
Lilong WangShuang Song

Abstract

Antibiotic treatment, as an important therapeutic intervention, can cause damage to the host microbiome and the intestinal mucosal barrier. In order to find a way to alleviate the side effects of antibiotics, the present study investigated the effects of fucoidan (ANP) isolated from Ascophyllum nodosum on gut microbiota dysbiosis and colonic inflammation induced by ciprofloxacin-metronidazole (CiMe) in C57BL/6J mice. Our results showed that dietary ANP prevented colon shortening, alleviated the colonic tissue damages, and partially reversed the alteration of gut microbiota by increasing the abundance of potentially beneficial bacteria, e.g., Ruminococcaceae_UCG_014 and Akkermansia and decreasing the abundance of harmful bacteria, e.g., Proteus and Enterococcus. ANP also suppressed the overproduction of TNF-α, IL-1β, and IL-6 and promoted the expression of IL-10. In addition, ANP reversed the decreased production of short-chain fatty acids in CiMe-treated mice. Furthermore, correlation analysis indicated the presence of critical gut microbiota, which played important roles in reducing the inflammation-related indices. Thus, the present study suggests that fucoidan isolated from Ascophyllum nodosum is effective in providing prote...Continue Reading

References

Aug 15, 1991·Analytical Biochemistry·T M Filisetti-Cozzi, N C Carpita
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Jul 1, 1962·The Biochemical Journal·K S DODGSON, R G PRICE
Feb 25, 2009·Inflammatory Bowel Diseases·H SokolJ Doré
Apr 13, 2010·Nature Methods·J Gregory CaporasoRob Knight
Jul 22, 2010·The American Journal of Gastroenterology·Chin Wen PngTimothy H J Florin
Sep 10, 2011·Bioinformatics·Tanja Magoč, Steven L Salzberg
Feb 26, 2013·Nature Reviews. Microbiology·Felix Sommer, Fredrik Bäckhed
Apr 22, 2015·Nature Immunology·Christopher A Hunter, Simon A Jones
Sep 22, 2015·Marine Drugs·Janet Helen FittonSamuel S Karpiniec
Oct 27, 2016·Nature Microbiology·Alexandra E LivanosMartin J Blaser
Feb 16, 2018·International Journal of Biological Macromolecules·Feng PanWei Wu
Mar 27, 2018·International Journal of Biological Macromolecules·Shuang SongChengrong Wen
Dec 29, 2018·EMBO Molecular Medicine·Aleksandra A KolodziejczykEran Elinav
Apr 12, 2019·International Journal of Biological Macromolecules·Yang ChengHaibin Tong
Apr 18, 2019·Immunity·Matthias FriedrichFiona Powrie
Jun 21, 2019·International Journal of Biological Macromolecules·Shuang SongZhenjun Zhu
Jul 13, 2019·Nature Reviews. Gastroenterology & Hepatology·Mary Ellen SandersRobert A Rastall
Aug 8, 2019·Nature Reviews. Immunology·Herbert TilgEran Elinav

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Citations

Jan 13, 2021·Molecular Microbiology·Jolene M GarberChristine M Szymanski
Mar 27, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Qiuhong KongSandra Pedisić
Aug 27, 2021·Marine Drugs·Jin-Young Yang, Sun Young Lim

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Methods Mentioned

BETA
PCR

Software Mentioned

Pro Plus
LEfSe
Uparse
vegan
Image
R
QIIME

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