Fucosylated oligosaccharides in mother's milk alleviate the effects of caesarean birth on infant gut microbiota

Scientific Reports
Katri KorpelaWillem M de Vos

Abstract

One of the most abundant components in human milk is formed by oligosaccharides, which are poorly digested by the infant. The oligosaccharide composition of breast milk varies between mothers, and is dependent on maternal secretor (FUT2) genotype. Secretor mothers produce milk containing α1-2 fucosylated human milk oligosaccharides, which are absent in the milk of non-secretor mothers. Several strains of bacteria in the infant gut have the capacity to utilise human milk oligosaccharides (HMOs). Here we investigate the differences in infant gut microbiota composition between secretor (N = 76) and non-secretor (N = 15) mothers, taking into account birth mode. In the vaginally born infants, maternal secretor status was not associated with microbiota composition. In the caesarean-born, however, many of the caesarean-associated microbiota patterns were more pronounced among the infants of non-secretor mothers compared to those of secretor mothers. Particularly bifidobacteria were strongly depleted and enterococci increased among the caesarean-born infants of non-secretor mothers. Furthermore, Akkermansia was increased in the section-born infants of secretor mothers, supporting the suggestion that this organism may degrade HMOs. The ...Continue Reading

References

Jan 10, 2001·The Journal of Allergy and Clinical Immunology·M KalliomäkiE Isolauri
Oct 9, 2001·The Journal of Allergy and Clinical Immunology·B BjörksténM Mikelsaar
Sep 18, 2003·FEMS Immunology and Medical Microbiology·Karen Manon LammersMassimo Campieri
Sep 3, 2004·The Journal of Pediatrics·Ardythe L MorrowDavid S Newburg
Jan 15, 2010·International Journal of Food Microbiology·Patricia LópezAna Suárez
May 7, 2010·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Thomas EiweggerZsolt Szépfalusi
Aug 17, 2010·Bioinformatics·Robert C Edgar
Feb 24, 2011·International Journal of Food Microbiology·David A Sela
Aug 13, 2011·The Journal of Biological Chemistry·Sadaki AsakumaMotomitsu Kitaoka
Sep 8, 2011·Analytical and Bioanalytical Chemistry·Dennis BlankClemens Kunz
Oct 18, 2011·International Journal of Systematic and Evolutionary Microbiology·Stefano MorandiMilena Brasca
Nov 1, 2011·Cell Host & Microbe·Angela MarcobalJustin L Sonnenburg
Jun 14, 2012·PLoS Pathogens·Seong Gyu JeonKiyoshi Takeda
Nov 30, 2012·Nucleic Acids Research·Christian QuastFrank Oliver Glöckner
Jul 31, 2013·Applied and Environmental Microbiology·Santiago Ruiz-MoyanoDavid A Mills
Feb 5, 2015·Journal of Pediatric Gastroenterology and Nutrition·Mei WangSharon M Donovan
May 15, 2015·Cell Host & Microbe·Fredrik BäckhedWang Jun
Feb 16, 2016·Microbial Pathogenesis·Muriel DerrienWillem M de Vos
Mar 16, 2016·The Biochemical Journal·Alexander J NollRichard D Cummings
Sep 8, 2016·Journal of Pediatric Gastroenterology and Nutrition·Clemens KunzSilvia Rudloff
Oct 6, 2016·The Journal of Allergy and Clinical Immunology·Antti E SeppoKirsi M Järvinen
Feb 8, 2018·Scientific Reports·Katri KorpelaWillem de Vos

❮ Previous
Next ❯

Citations

Oct 1, 2019·Current Opinion in Clinical Nutrition and Metabolic Care·Tomás CerdóCristina Campoy
Apr 23, 2020·Nutrients·Magdalena Orczyk-Pawiłowicz, Jolanta Lis-Kuberka
May 28, 2020·Nutrients·Yarden Golan, Yehuda G Assaraf
Jul 31, 2020·Nutrients·Elisabet Navarro-TapiaVicente Andreu-Fernández
Sep 12, 2020·Critical Reviews in Food Science and Nutrition·Emmanuel Pérez-EscalanteLuis Guillermo González-Olivares
Jul 7, 2019·Microorganisms·Starin McKeenWarren C McNabb
May 7, 2021·Food & Function·Stella A VerkhnyatskayaMarthe T C Walvoort
Jun 8, 2021·Frontiers in Immunology·Nafeesa MehmoodGraham R Wallace
Jun 11, 2021·Frontiers in Immunology·Anaïs RousseauxMarie Bodinier
Jul 3, 2021·Foods·Cristina SánchezMaría Paz Lorenzo
Aug 28, 2021·International Journal of Molecular Sciences·José Antonio CurielJuan Luis Arqués
Oct 21, 2021·Applied and Environmental Microbiology·Estefani LunaGilberto E Flores

❮ Previous
Next ❯

Methods Mentioned

BETA
amplicon sequencing
PCR

Software Mentioned

nlme
package mare
vegan
MASS
USEARCH
R
R package
mare

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.