fucosyltransferase1 and H-type complex carbohydrates modulate epithelial cell proliferation during prostatic branching morphogenesis

Developmental Biology
Paul C MarkerG R Cunha

Abstract

The prostate undergoes branching morphogenesis dependent on paracrine interactions between the prostatic epithelium and the urogenital mesenchyme. To identify cell-surface molecules that function in this process, monoclonal antibodies raised against epithelial cell-surface antigens were screened for antigen expression in the developing prostate and for their ability to alter development of prostates grown in serum-free organ culture. One antibody defined a unique expression pattern in the developing prostate and inhibited growth and ductal branching of cultured prostates by inhibiting epithelial cell proliferation. Expression cloning showed that this antibody binds fucosyltransferase1, an alpha-(1,2)-fucosyltransferase that synthesizes H-type structures on the complex carbohydrate modifications of some proteins and lipids. The lectin UEA I that binds H-type 2 carbohydrates also inhibited development of cultured prostates. These data demonstrate a previously unrecognized role for fucosyltransferase1 and H-type carbohydrates in controlling the spatial distribution of epithelial cell proliferation during prostatic branching morphogenesis. We also show that fucosyltransferase1 is expressed by epithelial cells derived from benign pr...Continue Reading

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Nov 24, 1979·Nucleic Acids Research·H C Birnboim, J Doly
Jan 1, 1976·Vox Sanguinis·A Y SinB H Sabo
Dec 1, 1977·Vox Sanguinis·S SringarmD Chandanayingyong
Jan 1, 1976·Vox Sanguinis·M Sathe, H M Bhatia
Nov 1, 1992·The Journal of Cell Biology·Y GavrieliS A Ben-Sasson
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·R D LarsenJ B Lowe
May 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·B Seed, A Aruffo
Mar 1, 1986·Developmental Biology·B A FendersonS Hakomori
Aug 1, 1987·Endocrine Reviews·G R CunhaY Sugimura
Jun 1, 1986·Biology of Reproduction·Y SugimuraA A Donjacour
May 1, 1963·Vox Sanguinis·C M GilesA H Atabuddin
Jan 1, 1968·Vox Sanguinis·E GandiniC Menini
Mar 1, 1969·Vox Sanguinis·H M PrettyR Guévin
Jan 1, 1983·Methods in Enzymology·M O DayhoffL T Hunt
Jun 21, 1994·Proceedings of the National Academy of Sciences of the United States of America·R J KellyJ B Lowe
Jan 18, 1994·Proceedings of the National Academy of Sciences of the United States of America·E Ioffe, P Stanley
Oct 1, 1996·Genome Research·C A HeidP M Williams
Oct 1, 1996·Genome Research·U E GibsonP M Williams
Dec 13, 1996·The Journal of Biological Chemistry·C J BieberichG Jay
Apr 1, 1997·Developmental Dynamics : an Official Publication of the American Association of Anatomists·C A PodlasekW Bushman
May 1, 1997·Developmental Dynamics : an Official Publication of the American Association of Anatomists·P J SciavolinoC Abate-Shen
Apr 21, 1999·The Journal of Urology·C A PodlasekW Bushman
Apr 24, 1999·Genes & Development·R Bhatia-GaurM M Shen
Aug 6, 1999·Developmental Biology·J P StephanJ P Mather
Aug 10, 2000·Nature·D J MoloneyT F Vogt
Jan 1, 1956·British Journal of Haematology·D M PARKIN

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Citations

Jun 21, 2005·Cell and Tissue Research·G P RisbridgerR A Taylor
Mar 21, 2003·Developmental Biology·Paul C MarkerGerald R Cunha
Nov 6, 2002·Biochimica Et Biophysica Acta·Carey Rodeheffer, Barry D Shur
Mar 12, 2002·Glycobiology·Eric G Berger
Jul 10, 2013·Acta Histochemica Et Cytochemica·Juliana Lúcia de Albuquerque VasconcelosEduardo Isidoro Carneiro Beltrão
Jan 18, 2013·PLoS Computational Biology·Sandra V BennunFrederick J Krambeck
Jan 25, 2005·The Journal of Steroid Biochemistry and Molecular Biology·Gerald R CunhaTakeshi Kurita
Aug 28, 2019·Cancers·Tyler S KeeleyEric Lau

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