Fueled by microtubules: does tubulin dimer/polymer partitioning regulate intracellular metabolism?

Cytoskeleton
Lynne CassimerisJohn Fong

Abstract

Microtubules (MTs) or their subunits, tubulin dimers, interact with multiple components that contribute to intracellular metabolic pathways. MTs are required for insulin-dependent transport of glucose transporter 4 to the plasma membrane, they bind most glycolytic enzymes and are required for translation of the mRNA encoding hypoxia inducible factor-1α. Tubulin dimers bind the voltage-dependent anion channel of the mitochondrial outer membrane; this channel functions in metabolite transport in and out of mitochondria. We hypothesize that tubulin partitioning between dimer and polymer pools regulates multiple steps in metabolism, where metabolic output is greatest when both tubulin dimers and MT polymers are present and reduced by drug treatments that disrupt this normal balance. Experimental evidence from these drug-induced changes in tubulin dimer/polymer partitioning supports our model for several metabolic steps. Signal transduction pathways that stabilize or destabilize MTs can shift the normal ratio between unpolymerized and polymerized tubulin dimers, and one downstream consequence of this shift in tubulin partitioning could be a change in metabolic output.

References

Feb 1, 1992·Journal of Bioenergetics and Biomembranes·M Y Liu, M Colombini
Jan 1, 1987·Annual Review of Biochemistry·P A Srere
Sep 1, 1988·The Journal of Cell Biology·L Pagliaro, D L Taylor
Nov 9, 1989·Biochimica Et Biophysica Acta·J L WalshH R Knull
Dec 1, 1984·The Journal of Cell Biology·W M SaxtonJ R McIntosh
Dec 1, 1993·Journal of Molecular Recognition : JMR·K W Volker, H R Knull
Nov 1, 1995·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·K W VolkerH R Knull
Jan 1, 1996·Ion Channels·M ColombiniM Forte
Sep 23, 1997·Diabetologia·G D Holman, M Kasuga
Jan 22, 1998·Experimental Cell Research·J WangL Pagliaro
Jan 27, 1999·Biochemical and Biophysical Research Communications·B G VértessyJ Ovádi
Feb 27, 1999·Current Opinion in Cell Biology·G G Gundersen, T A Cook
Dec 22, 1999·The American Journal of Physiology·P G Lloyd, C D Hardin
Feb 3, 2000·Proceedings of the National Academy of Sciences of the United States of America·F OroszJ Ovádi
Mar 30, 2001·The Journal of Biological Chemistry·A L OlsonG V Gibson
Jun 7, 2002·Biophysical Chemistry·Miguel A Aon, Sonia Cortassa
Dec 17, 2002·The Journal of Biological Chemistry·Janos KovacsJudit Ovadi
Apr 18, 2003·Nature·Joe Howard, Anthony A Hyman
May 14, 2003·The EMBO Journal·Sabina SemizMichael P Czech
May 15, 2003·American Journal of Physiology. Endocrinology and Metabolism·Hua AiThorkil Ploug
May 20, 2004·Experimental Cell Research·Martina Serlachius, Leif C Andersson
Aug 18, 2004·The Biochemical Journal·Josefa AndradeMargarida Barroso
Oct 14, 2004·The Journal of Cell Biology·Carolyn J LawrenceLinda Wordeman
Jun 2, 2005·Nature Reviews. Molecular Cell Biology·Niels Galjart
Nov 26, 2005·Biochimica Et Biophysica Acta·John J Lemasters, Ekhson Holmuhamedov
Mar 21, 2007·Biochimica Et Biophysica Acta·A KellerJ Ovádi
Apr 28, 2007·Free Radical Biology & Medicine·Gyorgy NagyAndras Perl
Jun 15, 2007·Cell Motility and the Cytoskeleton·James C Warren, Lynne Cassimeris
Jan 29, 2008·Current Cancer Drug Targets·Mary Ann Jordan, Kathy Kamath

❮ Previous
Next ❯

Citations

Feb 27, 2014·Biotechnology & Genetic Engineering Reviews·Ye FangStephen Benkovic
Mar 22, 2014·Parasitology Research·Olivia Reynoso-DucoingJavier R Ambrosio
Sep 12, 2014·Journal of Bioenergetics and Biomembranes·Kersti TeppTuuli Kaambre
Mar 16, 2016·Biochimica Et Biophysica Acta·Rafaela BagurRita Guzun
Dec 3, 2014·Journal of Theoretical Biology·Judit OláhJudit Ovádi
Feb 6, 2015·Frontiers in Physiology·Miguel A Aon, Sonia Cortassa
Jun 3, 2018·Cold Spring Harbor Perspectives in Biology·Holly V Goodson, Erin M Jonasson
Jan 21, 2021·Proceedings of the National Academy of Sciences of the United States of America·Maria Elena PeroFrancesca Bartolini

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.