Full-count PET recovery from low-count image using a dilated convolutional neural network

Medical Physics
Karl SpuhlerChuan Huang

Abstract

Positron emission tomography (PET) is an essential technique in many clinical applications that allows for quantitative imaging at the molecular level. This study aims to develop a denoising method using a novel dilated convolutional neural network (CNN) to recover full-count images from low-count images. We adopted similar hierarchical structures as the conventional U-Net and incorporated dilated kernels in each convolution to allow the network to observe larger, more robust features within the image without the requirement of downsampling and upsampling internal representations. Our dNet was trained alongside a U-Net for comparison. Both models were evaluated using a leave-one-out cross-validation procedure on a dataset of 35 subjects (~3500 slabs), which were obtained from an ongoing 18 F-Fluorodeoxyglucose (FDG) study. Low-count PET data (10% count) were generated by randomly selecting one-tenth of all events in the associated listmode file. Analysis was done on the static image from the last 10 minutes of emission data. Both low-count PET and full-count PET were reconstructed using ordered subset expectation maximization (OSEM). Objective image quality metrics, including mean absolute percent error (MAPE), peak signal-to-n...Continue Reading

References

Jun 28, 2005·Clinical Radiology·M R J SuryW K Chong
May 10, 2008·Pediatric Blood & Cancer·Elizabeth Robbins
Jan 5, 2012·EJNMMI Research·Frank HofheinzJörg van den Hoff
Dec 18, 2013·PloS One·Joyita DuttaQuanzheng Li
May 30, 2014·The Lancet Oncology·Heike Daldrup-LinkMarilyn Goske
Jun 29, 2015·Clinical Imaging·Markus Kajo SchulerJörg van den Hoff
Sep 1, 2015·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Beatrice BerthonC Ross Schmidtlein
May 4, 2016·NeuroImage·H MirzaalianY Rathi
May 18, 2016·IEEE Transactions on Bio-medical Engineering·Yan WangDinggang Shen
Aug 28, 2016·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Jianhua YanDavid Townsend
May 4, 2017·IEEE Transactions on Pattern Analysis and Machine Intelligence·Liang-Chieh ChenAlan L Yuille
Sep 18, 2018·IEEE Transactions on Medical Imaging· Kuang Gong Quanzheng Li
Dec 24, 2018·IEEE Transactions on Medical Imaging·Kuang GongQuanzheng Li
Jul 16, 2019·Physics in Medicine and Biology·Wenzhuo LuChi Liu
Aug 31, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Jianan CuiQuanzheng Li
Oct 15, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nikita NogovitsynGlenda M MacQueen
Feb 18, 2020·Journal of Affective Disorders·Valentina LorenzettiCynthia H Y Fu
Feb 23, 2020·Frontiers in Neurology·Min WangChanglian Tan

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Citations

May 11, 2021·Journal of Magnetic Resonance Imaging : JMRI·Mario Serrano-SosaChuan Huang

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