Full-field ERG and visual fields in patients 5 years after discontinuing vigabatrin therapy

Documenta Ophthalmologica. Advances in Ophthalmology
Ulrika KjellströmVesna Ponjavic

Abstract

In numerous studies vigabatrin medication has been associated with visual field constriction and alterations in the full-field electroretinogram (ff-ERG), but it is not clear whether these changes are reversible or not. The purpose of this study was to examine patients with visual field loss and reduced ff-ERG several years after discontinuing vigabatrin therapy, in order to investigate reversibility. Eight patients with visual field constriction and reduced cone responses measured by 30 Hz flicker ERG were examined with Goldmann perimetry and ff-ERG 4-6 years after discontinuing medication. The results were compared with investigations conducted during medication, 4-6 years previously. Statistical analysis was also used to compare the ff-ERG results of the patients, during treatment and at follow-up, with a group of 70 healthy subjects. Visual field constriction remained 4-6 years after discontinuing vigabatrin therapy. The amplitude of the 30 Hz flicker response also remained reduced on follow-up both compared with the results during treatment and with the control group. Moreover, the amplitude of the isolated rod response and the combined rod-cone response were decreased in the patients compared with the control group, durin...Continue Reading

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Citations

May 5, 2009·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Ulrika KjellströmVesna Ponjavic
Jan 26, 2011·Journal of Pediatric Ophthalmology and Strabismus·Ulrika KjellströmVesna Ponjavic
Jan 22, 2011·Acta Ophthalmologica·Linda MosengAnna Midelfart
Dec 28, 2017·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Rod Foroozan
Mar 3, 2010·CNS Drugs·Dean P Sarco, Blaise F D Bourgeois
Feb 14, 2020·Investigative Ophthalmology & Visual Science·Kore ChanGillian J McLellan
Dec 29, 2020·Ophthalmic Genetics·Ulrika KjellströmSten Andréasson

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