Full-field swept-source phase microscopy

Optics Letters
Marinko V SarunicJ A Izatt

Abstract

We present a full-field phase microscopy technique for quantitative nanoscale surface profiling of samples in reflection. This technique utilizes swept-source optical coherence tomography in a full-field common path interferometer for phase-stable cross-sectional acquisition without scanning. Subwavelength variations in surface sample features are measured without interference from spurious reflections by processing the interferometric phase at a selected depth plane, providing a 1.3 nm stability for high signal-to-noise ratio surface features. Nanoscale imaging was demonstrated by measuring the location of receptor sites on a DNA assay biochip and the surface topography of erythrocytes in a blood smear.

References

Dec 9, 2004·Optics Letters·Gabriel PopescuMichael S Feld
Jun 11, 2005·Optics Letters·Michael A ChomaJoseph A Izatt
Jun 11, 2005·Optics Letters·Takahiro IkedaMichael S Feld
Apr 21, 2003·Optics Express·R LeitgebAdolf Fercher
Feb 21, 2005·Optics Express·Branislav GrajciarRainer Leitgeb

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Citations

Nov 25, 2011·Journal of Biomedical Optics·Shikhar UttamYang Liu
Jul 14, 2012·Optical Engineering : the Journal of the Society of Photo-optical Instrumentation Engineers·Nathan HagenTomasz S Tkaczyk
Jan 26, 2016·Sensors·Hyung Seok LeeChang-Seok Kim
Jul 5, 2011·Journal of Biomedical Optics·Rui WangBruce Z Gao
Mar 9, 2017·Biomedical Optics Express·Thomas Klein, Robert Huber
Mar 9, 2017·Biomedical Optics Express·Olivier ThouveninA Claude Boccara
Apr 15, 2010·Optics Express·Simon Tuohy, Adrian Gh Podoleanu
Jun 3, 2010·Applied Optics·Maciej Wojtkowski
Oct 19, 2019·Current Gene Therapy·Subrata BatabyalSamarendra Mohanty
Nov 2, 2014·Optics Letters·Youngwoon ChoiZahid Yaqoob
Apr 20, 2011·Optics Express·Zahid YaqoobMichael S Feld
Aug 20, 2010·Optics Express·Xiquan CuiChanghuei Yang
Apr 9, 2014·Journal of Biomedical Optics·Suho RyuChulmin Joo
Oct 17, 2014·Optics Express·Nathan D ShemonskiStephen A Boppart
Feb 3, 2016·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Shikhar Uttam, Yang Liu
Mar 16, 2007·Optics Letters·Audrey K Ellerbee, Joseph A Izatt
Apr 22, 2011·Applied Optics·Andra St QuintinMarinko V Sarunic
Oct 6, 2012·Optics Express·Nektarios KoukourakisMartin R Hofmann
Jul 10, 2012·Optics Express·William A Ling, Audrey K Ellerbee
Apr 2, 2014·Optics Letters·Matthew T RinehartAdam Wax
Oct 20, 2017·Applied Optics·Chengshuai Li, Yizheng Zhu
May 31, 2019·Biomedical Optics Express·R A Leitgeb
Apr 23, 2019·Optica·Youngwoon ChoiZahid Yaqoob
Mar 25, 2020·Biomedical Optics Express·Alex MatlockLei Tian
Feb 20, 2007·Optics Letters·Chulmin JooJohannes F de Boer
Sep 15, 2015·Applied Optics·Alexander S MachikhinLudmila I Burmak
Jul 25, 2017·Biomedical Optics Express·Zhiyuan ShenYonghong He
Jul 23, 2007·Optics Express·Adrian H BachmannRainer A Leitgeb

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