Full-genome analysis of hepatitis C virus in HIV-coinfected hemophiliac Japanese patients

Hepatology Research : the Official Journal of the Japan Society of Hepatology
Yuki IshidaHiroyuki Gatanaga

Abstract

More than 1400 Japanese hemophiliacs acquired HIV infection around 1983 through contaminated blood products imported from the United States, most of whom also acquired hepatitis C virus (HCV) infection. To delineate the HCV genetic relations in HIV-coinfected hemophiliacs, we analyzed stocked plasma samples of the patients seen at the largest referral center for HIV care in Japan. HCV full-genome sequences were amplified and determined using next-generation sequencing. HCV genotyping and phylogenetic analysis of thus obtained sequences were performed. The results of these hemophiliacs were compared with those of previously-studied HIV-coinfected Japanese non-hemophiliacs who had undergone similar analysis of HCV full-genome sequences. From 1997 to the end of 2017, 72 HIV-infected Japanese hemophiliacs regularly visited our Outpatient Clinic. Of these, 51 patients had detectable plasma HCV-RNA. HCV full-genome was successfully amplified and sequenced in 50 patients. Not only HCV genotypes 1b (28%) and 2a (6%), which are common in Japan, but also HCV genotypes 1a (32%) and 3a (22%) were identified at high frequency. A single case of inter-genotypic recombinant form (2b/1a) and a single case of mixed infection (1a and 3a) were als...Continue Reading

References

Jul 30, 2004·The New England Journal of Medicine·Francesca J TorrianiUNKNOWN APRICOT Study Group
Jul 30, 2004·The New England Journal of Medicine·Raymond T ChungUNKNOWN AIDS Clinical Trials Group A5071 Study Team
Jul 15, 2006·Journal of Virology·Suwanna NoppornpanthBart L Haagmans
Sep 26, 2006·Journal of Medical Virology·Seiji KageyamaHiroshi Ichimura
Feb 3, 2007·Journal of Virology·Florence Legrand-AbravanelJacques Izopet
Aug 5, 2008·International Journal of Hematology·Shinobu TatsunamiMasashi Taki
Oct 22, 2008·The Journal of Infectious Diseases·Fuat KurbanovMasashi Mizokami
May 20, 2009·Bioinformatics·Heng Li, Richard Durbin
Jun 2, 2009·Nucleic Acids Research·Luiz Carlos Junior AlcantaraTulio de Oliveira
Oct 5, 2011·Virology Journal·Dipankar BhattacharyaWilliam M Rehrauer
Apr 21, 2012·Briefings in Bioinformatics·Helga ThorvaldsdóttirJill P Mesirov
Sep 15, 2012·BMC Genomics·Xiao YangMatthew R Henn
Mar 7, 2014·Epidemiology and Infection·H ToyodaJ Tanaka
Aug 3, 2014·Journal of Hepatology·Erin GowerHomie Razavi
Aug 8, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Charlotte HedskogHongmei Mo
Aug 15, 2014·Nucleic Acids Research·Daniel StruckDanielle Perez Bercoff
Apr 1, 1997·Haemophilia : the Official Journal of the World Federation of Hemophilia·S TakayamaK Yamada
Dec 17, 2016·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Azusa Nagao, Hideji Hanabusa
Dec 15, 2018·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Yuki IshidaHiroyuki Gatanaga
May 11, 2019·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Hisashi IshidaEiji Mita

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.