Full-genome sequence and analysis of a novel human rhinovirus strain within a divergent HRV-A clade.

Archives of Virology
Jennifer A RatheStephen B Liggett

Abstract

Genome sequences of human rhinoviruses (HRV) have primarily been from stocks collected in the 1960s, with genomes and phylogeny of modern HRVs remaining undefined. Here, two modern isolates (hrv-A101 and hrv-A101-v1) collected approximately 8 years apart were sequenced in their entirety. Incorporation into our full-genome HRV alignment with subsequent phylogenetic network inference indicated that these represent a unique HRV-A, localized within a distinct divergent clade. They appear to have resulted from recombination of the hrv-65 and hrv-78 lineages. These results support our contention that there are unrecognized distinct HRV-A strains, and that recombination is evident in currently circulating strains.

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Citations

Mar 4, 2014·PloS One·Vaishali P WamanUrmila Kulkarni-Kale
Feb 28, 2013·Archives of Virology·Chloe L McIntyrePeter Simmonds
May 17, 2013·The Journal of General Virology·Chloe L McIntyrePeter Simmonds
Mar 3, 2015·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Wei-Ju ChenEugene V Millar
May 18, 2010·The Journal of Allergy and Clinical Immunology·Ann C PalmenbergStephen B Liggett
Sep 16, 2016·Journal of Virology·Cibele M GaidoBelinda J Hales
Jun 27, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Dillon Charles AdamJen Kok

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