Full-genome sequences of hepatitis B virus subgenotype D3 isolates from the Brazilian Amazon Region

Memórias do Instituto Oswaldo Cruz
Natália SpitzNatalia Motta Araujo

Abstract

The Brazilian Amazon Region is a highly endemic area for hepatitis B virus (HBV). However, little is known regarding the genetic variability of the strains circulating in this geographical region. Here, we describe the first full-length genomes of HBV isolated in the Brazilian Amazon Region; these genomes are also the first complete HBV subgenotype D3 genomes reported for Brazil. The genomes of the five Brazilian isolates were all 3,182 base pairs in length and the isolates were classified as belonging to subgenotype D3, subtypes ayw2 (n = 3) and ayw3 (n = 2). Phylogenetic analysis suggested that the Brazilian sequences are not likely to be closely related to European D3 sequences. Such results will contribute to further epidemiological and evolutionary studies of HBV.

References

Mar 9, 2005·Vaccine·Anna KramvisGuido François
Jan 14, 2011·Journal of Gastroenterology and Hepatology·Chih-Lin Lin, Jia-Horng Kao
May 5, 2011·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Natalia M AraujoAlan Kay
Apr 28, 2012·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Dennis Armando BertoliniJoão Renato Rebello Pinho
Sep 18, 2012·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Mukhlid Yousif, Anna Kramvis
Mar 30, 2013·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Weifeng ShiDesmond G Higgins
Oct 18, 2013·Molecular Biology and Evolution·Koichiro TamuraSudhir Kumar

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Citations

Sep 22, 2019·Viruses·Barbara V LagoFrancisco C A Mello

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Datasets Mentioned

BETA
KP090177-KP090181
AY233278
AB112066
X75664
AB056513
AY090454
FJ023660
AB486012

Software Mentioned

SimPlot
Bootscan
MEGA

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