Abstract
Although the relationship between hyperparathyroidism and hypertension has been described for decades, the role of hyperparathyroidism in hypertension in dialysis is still unclear. Following the case of a severely hypertensive dialysis patient, in which parathyroidectomy (PTX) corrected the metabolic imbalance and normalized blood pressure (BP), we tried to contextualize our observation with a systematic review of the recent literature on the effect of PTX on BP. A dialysis patient, aged 19 years at the time of this report, with chronic kidney disease (CKD) from childhood; he was an early-preterm baby with very low birth weight (910 g), and is affected by a so-far unidentified familial nephropathy. He started dialysis in emergency at the age of 17. Except for low-dose Bisoprolol, he refused all chronic medication; hypertension (165-200/90-130 mmHg) did not respond to attainment of dry weight (Kt/V > 1.7; BNP 70-200 pg/ml pre-dialysis). He underwent subtotal PTX 1 year after dialysis start; after PTX, his blood pressure stabilized in the 100-140/50-80 range, and is normal without treatment 5 months later. Our patient has some peculiar features: he is young, has a non-immunologic disease, poor compliance to drug therapy, excellen...Continue Reading
References
Jan 1, 1986·American Journal of Nephrology·S G MassryV M Campese
May 1, 1984·The American Journal of Physiology·D H Ellison, D A McCarron
Jan 1, 1993·Nephron·F PizzarelliQ Maggiore
Jun 1, 1996·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D J GoldsmithP Ackrill
Mar 3, 1998·American Journal of Nephrology·O IfuduE A Friedman
Oct 16, 1999·Archives of Surgery·F F ChouJ B Chen
Jun 16, 2001·Nephron·G CoenF Taggi
Sep 10, 2002·Nephron·Jaume AlmirallGabriel Marques
Sep 25, 2002·Transplantation Proceedings·U SaatciM Haberal
Apr 17, 2003·Kidney & Blood Pressure Research·Vlado PerkovicGavin J Becker
Jul 31, 2004·Journal of the American Society of Nephrology : JASN·Geoffrey A BlockGlenn M Chertow
Feb 4, 2005·Endocrine Reviews·Timothy M MurrayF Richard Bringhurst
Dec 21, 2007·Journal of the American Society of Nephrology : JASN·Sharon M Moe, Neal X Chen
Jul 15, 2009·Lancet·William D Fraser
May 15, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jürgen FloegeUNKNOWN ARO Investigators
Sep 10, 2010·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Rosa Maria De SantoMassimo Cirillo
Apr 16, 2013·The Journal of Clinical Endocrinology and Metabolism·A J van BallegooijenI A Brouwer
May 9, 2013·Journal of Human Hypertension·A LeibaE J Holtzman
May 11, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Jing ZhangNingning Wang
Aug 14, 2013·PloS One·Patricia Taschner GoldensteinRosa Maria Affonso Moysés
Oct 2, 2013·Kidney & Blood Pressure Research·Chia-Jen ShihChih-Yu Yang
Oct 10, 2013·Clinical Endocrinology·Ho-Cheng LinPo-Tsang Lee
Oct 2, 2014·Hemodialysis International·Maria Júlia C L N AraújoRosa M A Moysés
Mar 19, 2015·Kidney International·Hirotaka KomabaMasafumi Fukagawa
Feb 6, 2017·Seminars in Fetal & Neonatal Medicine·Stacy RosenblumKimberly Reidy