Full normalization of severe hypertension after parathryoidectomy - a case report and systematic review

BMC Nephrology
Andreea Corina SofronieGiorgina Barbara Piccoli

Abstract

Although the relationship between hyperparathyroidism and hypertension has been described for decades, the role of hyperparathyroidism in hypertension in dialysis is still unclear. Following the case of a severely hypertensive dialysis patient, in which parathyroidectomy (PTX) corrected the metabolic imbalance and normalized blood pressure (BP), we tried to contextualize our observation with a systematic review of the recent literature on the effect of PTX on BP. A dialysis patient, aged 19 years at the time of this report, with chronic kidney disease (CKD) from childhood; he was an early-preterm baby with very low birth weight (910 g), and is affected by a so-far unidentified familial nephropathy. He started dialysis in emergency at the age of 17. Except for low-dose Bisoprolol, he refused all chronic medication; hypertension (165-200/90-130 mmHg) did not respond to attainment of dry weight (Kt/V > 1.7; BNP 70-200 pg/ml pre-dialysis). He underwent subtotal PTX 1 year after dialysis start; after PTX, his blood pressure stabilized in the 100-140/50-80 range, and is normal without treatment 5 months later. Our patient has some peculiar features: he is young, has a non-immunologic disease, poor compliance to drug therapy, excellen...Continue Reading

References

Jan 1, 1986·American Journal of Nephrology·S G MassryV M Campese
May 1, 1984·The American Journal of Physiology·D H Ellison, D A McCarron
Jan 1, 1993·Nephron·F PizzarelliQ Maggiore
Jun 1, 1996·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D J GoldsmithP Ackrill
Mar 3, 1998·American Journal of Nephrology·O IfuduE A Friedman
Sep 10, 2002·Nephron·Jaume AlmirallGabriel Marques
Apr 17, 2003·Kidney & Blood Pressure Research·Vlado PerkovicGavin J Becker
Jul 31, 2004·Journal of the American Society of Nephrology : JASN·Geoffrey A BlockGlenn M Chertow
Dec 21, 2007·Journal of the American Society of Nephrology : JASN·Sharon M Moe, Neal X Chen
Jul 15, 2009·Lancet·William D Fraser
May 15, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jürgen FloegeUNKNOWN ARO Investigators
Sep 10, 2010·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Rosa Maria De SantoMassimo Cirillo
Apr 16, 2013·The Journal of Clinical Endocrinology and Metabolism·A J van BallegooijenI A Brouwer
May 11, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Jing ZhangNingning Wang
Aug 14, 2013·PloS One·Patricia Taschner GoldensteinRosa Maria Affonso Moysés
Oct 2, 2014·Hemodialysis International·Maria Júlia C L N AraújoRosa M A Moysés
Mar 19, 2015·Kidney International·Hirotaka KomabaMasafumi Fukagawa
Feb 6, 2017·Seminars in Fetal & Neonatal Medicine·Stacy RosenblumKimberly Reidy

❮ Previous
Next ❯

Citations

Mar 4, 2020·Journal of Clinical Medicine·Mariadelina SimeoniGiorgio Fuiano
Feb 23, 2020·International Journal of Environmental Research and Public Health·Giorgina Barbara PiccoliNicola Panocchia

❮ Previous
Next ❯

Software Mentioned

Metanalyst Beta

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.