Full-Process Radiosensitization Based on Nanoscale Metal-Organic Frameworks

ACS Nano
Teng GongWenbo Bu

Abstract

Full-process radiosensitization, that is, pre-increasing radiation sensitivity of cancer cells, magnifying •OH formation during ionizing irradiation, and intervention on the resultant DNA repair for final cells death, could enhance the overall radiotherapeutic effects, but has not yet been achieved. Herein, Hf-nMOFs with Fe3+ ions uniformly dispersed (Hf-BPY-Fe) were constructed to integratedly improve radiotherapeutic effects via a multifaceted mechanism. The in vitro experiments demonstrated that persistent reactive oxygen species stress from Hf-BPY-Fe-activated in situ Fenton reaction reassorted cell cycle distribution, consequently contributing to increased tumoral radiosensitivity to photon radiation. Upon irradiation during the course of radiation therapy, Hf4+ in Hf-BPY-Fe gave substantial amounts of high-energy electrons, which partially converted H2O to •OH and, meanwhile, relaxed to a low-energy state in nMOF pores, leading to an electron-rich environment. These aggregated electrons facilitated the reduction from Fe3+ to Fe2+ and further promoted the production of •OH in the Fenton process to attack DNA. The Hf-BPY-Fe postponed the DNA damage response process by interfering with certain proteins involved in the DNA re...Continue Reading

References

May 5, 2012·Chemistry : a European Journal·Gustavo RamaMiguel Vázquez López
Sep 12, 2014·Inorganic Chemistry·Christian AndriamiadamananaFrédéric Sauvage
Jan 23, 2016·Water Research·Konstantinos V PlakasAnastasios J Karabelas
Aug 16, 2016·Biomaterials·Anastasia K HauserJ Zach Hilt
Nov 12, 2016·Nature Reviews. Cancer·Jinjun ShiOmid C Farokhzad
Jun 24, 2017·Advanced Materials·Guosheng SongZhuang Liu
Dec 12, 2017·Trends in Pharmacological Sciences·Hao WangXiao-Dong Zhang
May 4, 2018·ACS Central Science·Shuai YuanHong-Cai Zhou
Aug 22, 2018·Accounts of Chemical Research·Tasha DrakeWenbin Lin
Aug 30, 2018·Advanced Materials·Jiani XieYuliang Zhao
Oct 26, 2018·Nature Reviews. Clinical Oncology·Patrick G PiliéTimothy A Yap
Nov 30, 2018·Journal of the American Chemical Society·Guangxu LanWenbin Lin
Apr 19, 2019·Journal of the American Chemical Society·Guangxu LanWenbin Lin
Jun 15, 2019·Journal of the American Chemical Society·Li-Sen LinXiaoyuan Chen
Jul 8, 2019·Advanced Drug Delivery Reviews·Allison N DuRossConroy Sun

❮ Previous
Next ❯

Citations

Aug 19, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Lile DongGuobin Hong
Nov 21, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Lijuan ZengGan Tian
Sep 10, 2020·Chemistry : a European Journal·Megan J NeufeldConroy Sun
Jan 25, 2021·Advanced Drug Delivery Reviews·Taskeen Iqbal JanjuaAmirali Popat
Mar 10, 2021·Angewandte Chemie·Peng GaoBo Tang
May 20, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Shuying LiConghua Xie
Jun 30, 2021·Journal of Nanobiotechnology·Jingqi XinFeifei An
Jan 19, 2021·ACS Biomaterials Science & Engineering·Xiao LiuHaijun Yu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Cycle Pathways

Cell cycle is a complex process regulated by several signal transduction pathways and enzymes. Here is the latest research on regulation of cell cycle and cell cycle pathways.

Related Papers

Revista de urología
J NORIEGA LIMON
JAMA : the Journal of the American Medical Association
C C Wang
Marseille médical
E GASCARD
Le Poumon et le coeur
P LAVALH LIEUTAUD
© 2021 Meta ULC. All rights reserved