Full sequencing and haplotype analysis of MAPT in Parkinson's disease and rapid eye movement sleep behavior disorder

Movement Disorders : Official Journal of the Movement Disorder Society
Jiao LiZiv Gan-Or

Abstract

MAPT haplotypes are associated with PD, but their association with rapid eye movement sleep behavior disorder is unclear. To study the role of MAPT variants in rapid eye movement sleep behavior disorder. Two cohorts were included: (A) PD (n = 600), rapid eye movement sleep behavior disorder (n = 613) patients, and controls (n = 981); (B) dementia with Lewy bodies patients with rapid eye movement sleep behavior disorder (n = 271) and controls (n = 950). MAPT-associated variants and the entire coding sequence of MAPT were analyzed. Age-, sex-, and ethnicity-adjusted analyses were performed to examine the association between MAPT, PD, and rapid eye movement sleep behavior disorder. MAPT-H2 variants were associated with PD (odds ratios: 0.62-0.65; P = 0.010-0.019), but not with rapid eye movement sleep behavior disorder. In PD, the H1 haplotype odds ratio was 1.60 (95% confidence interval: 1.12-2.28; P = 0.009), and the H2 odds ratio was 0.68 (95% confidence interval: 0.48-0.96; P = 0.03). The H2/H1 haplotypes were not associated with rapid eye movement sleep behavior disorder. Our results confirm the protective effect of the MAPT-H2 haplotype in PD, and define its components. Furthermore, our results suggest that MAPT does not pla...Continue Reading

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Citations

Jun 25, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Michael G HeckmanOwen A Ross
Oct 29, 2019·Annals of Neurology·Lynne KrohnZiv Gan-Or
Oct 2, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Kheireddin MuftiZiv Gan-Or
Aug 9, 2020·Annals of Clinical and Translational Neurology·Angela B DeutschlanderOwen A Ross
Dec 24, 2019·Journal of Parkinson's Disease·Ziv Gan-OrEdward A Fon
Dec 23, 2020·Brain : a Journal of Neurology·Uladzislau RudakouZiv Gan-Or
Jul 1, 2020·Neurobiology of Disease·Michele T Hu
Jan 19, 2021·Journal of Molecular Neuroscience : MN·Lina PanZhentao Zhang
Jan 6, 2021·Neurology·Kheireddin MuftiZiv Gan-Or
May 15, 2021·Sleep Medicine Clinics·Alex IranzoSabela Novo

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