Full surface embedding of gold clusters on silicon nanowires for efficient capture and photothermal therapy of circulating tumor cells

Nano Letters
Gyeong-Su ParkKinam Kim

Abstract

We report on rapid thermal chemical vapor deposition growth of silicon nanowires (Si NWs) that contain a high density of gold nanoclusters (Au NCs) with a uniform coverage over the entire length of the nanowire sidewalls. The Au NC-coated Si NWs with an antibody-coated surface obtain the unique capability to capture breast cancer cells at twice the highest efficiency currently achievable (~88% at 40 min cell incubation time) from a nanostructured substrate. We also found that irradiation of breast cancer cells captured on Au NC-coated Si NWs with a near-infrared light resulted in a high mortality rate of these cancer cells, raising a fine prospect for simultaneous capture and plasmonic photothermal therapy for circulating tumor cells.

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Citations

Apr 30, 2013·Cancer Letters·Zhen-yu Zhang, Hai-yan Ge
Jun 20, 2014·Nano Today·Lixue WangYuan Wan
Aug 12, 2014·Accounts of Chemical Research·Millicent LinHsian-Rong Tseng
Jun 28, 2015·Nanomedicine : Nanotechnology, Biology, and Medicine·Mohan SinghDaniel S Elson
Jul 3, 2015·Nanomedicine·Fei PengYao He
Aug 28, 2013·Biotechnology Advances·Qin ZhengYuan Wan
Mar 7, 2017·Biochemistry. Biokhimii︠a︡·L A Dykman, N G Khlebtsov
Jul 22, 2017·ACS Sensors·Ciro Chiappini
Mar 6, 2015·Chemical Society Reviews·Li Wu, Xiaogang Qu
Feb 15, 2018·Scientific Reports·Pradipta Ranjan RautaAditya Chaubey
Feb 13, 2016·Oncotarget·Joshua M GammonChristopher M Jewell
Jun 14, 2020·Journal of Functional Biomaterials·Giuseppe ArrabitoBruno Pignataro
Jul 21, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ya WangXian-Zheng Zhang
Sep 24, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Tong LiYong-Kuan Gong
Feb 8, 2014·Chemical Society Reviews·Xueli Liu, Shutao Wang
Jul 28, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jingchao LiGuoping Chen
Apr 21, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiaolong TuZhijun Zhang
Aug 4, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiangling LiFanmao Liu
Oct 22, 2013·Nanotechnology·So Yeon Kim, Eun Gyeong Yang

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