Full-term pregnancy induces a specific genomic signature in the human breast

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Jose RussoIrma H Russo

Abstract

Breast cancer risk has traditionally been linked to nulliparity or late first full-term pregnancy, whereas young age at first childbirth, multiparity, and breast-feeding are associated with a reduced risk. Early pregnancy confers protection by inducing breast differentiation, which imprints a specific and permanent genomic signature in experimental rodent models. For testing whether the same phenomenon was detectable in the atrophic breast of postmenopausal parous women, we designed a case-control study for the analysis of the gene expression profile of RNA extracted from epithelial cells microdissected from normal breast tissues obtained from 18 parous and 7 nulliparous women free of breast pathology (controls), and 41 parous and 8 nulliparous women with history of breast cancer (cases). RNA was hybridized to cDNA glass microarrays containing 40,000 genes; arrays were scanned and the images were analyzed using ImaGene software version 4.2. Normalization and statistical analysis were carried out using Linear Models for Microarrays and GeneSight software for hierarchical clustering. The parous control group contained 2,541 gene sequences representing 18 biological processes that were differentially expressed in comparison with t...Continue Reading

Citations

May 10, 2011·Breast Cancer Research and Treatment·Mirjam D K AlsakerLars J Vatten
Apr 5, 2013·Breast Cancer Research and Treatment·Akiko Kawano NagatsumaYasuhiro Fujiwara
Aug 2, 2011·Journal of Mammary Gland Biology and Neoplasia·Irma H Russo, Jose Russo
Nov 20, 2009·American Journal of Epidemiology·Jorge E ChavarroKarin B Michels
Jan 27, 2011·American Journal of Epidemiology·Sara J SchonfeldKala Visvanathan
Aug 12, 2010·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Christian R LoehbergPeter A Fasching
Oct 13, 2009·Health Physics·Roy E Shore
Aug 18, 2010·Cancer Research·Paolo TonioloAnnekatrin Lukanova
Apr 16, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Carol A Davis-DaoVictoria K Cortessis
Oct 13, 2012·BMC Medical Genomics·Suraj PeriJose Russo
Jan 6, 2010·Environmental Health Perspectives·Robert A HiattUNKNOWN Breast Cancer and the Environment Research Centers
Apr 8, 2014·Genes·Jose RussoIrma H Russo
Dec 21, 2013·Trends in Molecular Medicine·Fabienne Meier-Abt, Mohamed Bentires-Alj
Jul 16, 2010·Journal of Women's Health·Lawrence F BielakPatricia A Peyser
Dec 2, 2014·Breast Cancer Research : BCR·Hatem A Azim, Ann H Partridge
Jul 2, 2015·Journal of the Neurological Sciences·P W O'MalleyO Nesic
May 20, 2009·International Journal of Cancer. Journal International Du Cancer·Subhojit DeyAleyamma Mathew
Jul 2, 2009·International Journal of Cancer. Journal International Du Cancer·Salma ButtJonas Manjer
Oct 26, 2011·International Journal of Cancer. Journal International Du Cancer·Jose RussoIrma H Russo
Jul 21, 2015·Journal of Mammary Gland Biology and Neoplasia·Lisa M Arendt, Charlotte Kuperwasser
Mar 2, 2018·International Journal of Cancer. Journal International Du Cancer·Mustapha AbubakarMontserrat Garcia-Closas
Apr 25, 2018·The International Journal of Biological Markers·Yaser MansooriJavad Tavakkoly-Bazzaz
Sep 10, 2009·British Journal of Cancer·A KauppilaE Pukkala
Feb 11, 2018·Breast Cancer Research and Treatment·H De MulderP Neven
Jun 6, 2014·The American Journal of Clinical Nutrition·Mark Messina
Aug 16, 2016·Hormone Molecular Biology and Clinical Investigation·Jose Russo
Oct 22, 2019·Hormones & Cancer·Elizabeth Slocum, Doris Germain
Oct 26, 2018·Nature Communications·Anders HusbyMads Melbye
Feb 17, 2019·Breast Cancer Research : BCR·Bastien NguyenChristos Sotiriou

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