Full Viral Suppression, Low-Level Viremia, and Quantifiable Plasma HIV-RNA at the End of Pregnancy in HIV-Infected Women on Antiretroviral Treatment

AIDS Research and Human Retroviruses
Silvia BaroncelliMarco Floridia

Abstract

There is limited information on full viral suppression and low-level HIV-RNA viremia in HIV-infected women at the end of pregnancy. We investigated HIV-RNA levels close to delivery in women on antiretroviral treatment in order to define rates of complete suppression, low-level viremia, and quantifiable HIV-RNA, exploring as potential determinants some clinical and viroimmunological variables. Plasma samples from a national study in Italy, collected between 2003 and 2012, were used. According to plasma HIV-RNA levels, three groups were defined: full suppression (target not detected), low-level viremia (target detected but <37 copies/ml), and quantifiable HIV-RNA (≥37 copies/ml). Multivariable logistic regression was used to define determinants of full viral suppression and of quantifiable HIV-RNA. Among 107 women evaluated at a median gestational age of 35 weeks, 90 (84.1%) had HIV-RNA <37 copies/ml. Most of them (59/90, 65.6%) had full suppression, with the remaining (31/90, 34.4%) showing low-level viremia (median: 11.9 copies/ml; IQR 7.4-16.3). Among the 17 women with quantifiable viral load, median HIV-RNA was 109 copies/ml (IQR 46-251), with only one case showing resistance (mutation M184V; rate: 9.1%). In multivariable ana...Continue Reading

References

Mar 4, 2006·Epidemiology and Infection·M FloridiaUNKNOWN Italian Group on Surveillance on Antiretroviral Treatment in Pregnancy
May 23, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Deven PatelMarie-Louise Newell
Sep 11, 2010·AIDS·Keri N AlthoffUNKNOWN North American AIDS Cohorts Collaboration on Research, Design (NA-ACCORD)
Jan 18, 2011·HIV Clinical Trials·Marco FloridiaUNKNOWN Italian Group on Surveillance on Antiretroviral Treatment in Pregnancy
Oct 12, 2011·The Journal of Antimicrobial Chemotherapy·Nicola GianottiAntonella Castagna
Dec 14, 2011·Current Opinion in Infectious Diseases·Tomas Doyle, Anna Maria Geretti
Jan 13, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Tomas DoyleAnna Maria Geretti
Mar 24, 2012·AIDS·Phillip J ReadUNKNOWN London HIV Perinatal Research Group
Apr 7, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Franco MaggioloSebastiano Leone
Mar 13, 2013·European Journal of Public Health·Karoline Aebi-PoppClaire Thorne
Jul 12, 2013·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Karoline Aebi-PoppUNKNOWN Swiss Mother & Child HIV Cohort Study
Jul 31, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·N GianottiA Castagna

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BETA
cesarean section
Genotyping

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SPSS

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