Fullerol C60 (OH)24 nanoparticles modulate aflatoxin B1 biosynthesis in Aspergillus flavus

Scientific Reports
Tihomir KovačBojan Šarkanj

Abstract

The water soluble fullerene C60 daughter product - fullerols C60(OH)24 (FNP) possesses a great potential of modifying secondary metabolites biosynthesis. In order to clarify the extent of interaction, the impact of FNP (10, 100 and 1000 ng mL-1) on aflatoxin production and the available precursors of biosynthesis pathway from Aspergillus flavus NRRL 3251 was determined, in both the mycelia and yeast extract sucrose (YES) medium, during a 168-hour growth period at 29 °C in the dark. The FNP of 8 nm in diameter, and with a zeta potential of -33 mV affected mycelial growth at 1000 ng mL-1 while conidia production was slightly affected at 10 ng mL-1. The FNP effect on aflatoxin and it biosynthetic precursors was concentration dependent and alteration of the sterigmatocystin (ST) export from the cell was observed. Most of the monitored aflatoxin precursors, except norsolorinic acid, were detected in both mycelia and YES medium. However, observed precursor concentrations were much higher in mycelia, with exception of ST. The study shows the loss of FNP antioxidative effect after 120 hours of growth, and strong concentration dependent aflatoxigenic effect after that time. Thus, this data is relevant to guide future considerations on F...Continue Reading

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Citations

Jun 11, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Belal J MuhialdinAnis Shobirin Meor Hussin
Feb 7, 2020·Applied Microbiology and Biotechnology·Rubaiya Jesmin, Anindya Chanda
Apr 3, 2020·Environmental Science and Pollution Research International·Giorgio SpadolaDominga Rogolino

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Methods Mentioned

BETA
AFM
electrophoretic light scattering

Software Mentioned

Statistica

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Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

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