Fully automated predictive intelligent control of oxygenation (PRICO) in resuscitation and ventilation of preterm lambs

Pediatric Research
Matthias C HüttenBoris W Kramer

Abstract

Hyperoxia and hypoxia influence morbidity and mortality of preterm infants. Automated closed-loop control of the fraction of inspired oxygen (FiO(2)) has been shown to facilitate oxygen supplementation in the neonatal intensive care unit (NICU), but has not yet been tested during preterm resuscitation. We hypothesized that fully automated FiO(2) control based on predefined oxygen saturation (SpO(2)) targets was applicable in both preterm resuscitation and ventilation. Twenty-two preterm lambs were operatively delivered and intubated in a modified EXIT procedure. They were randomized to receive standardized resuscitation with either automated or manual FiO(2) control, targeting SpO(2) according to the Dawson curve in the first 10 min and SpO(2) 90-95% hereafter. Automated FiO(2) control also was applied during surfactant replacement therapy and subsequent ventilation. Time within target range did not differ significantly between manual and automated FiO(2) control during resuscitation, however automated FiO(2) control significantly avoided hyperoxia. Automated FiO(2) control was feasible during surfactant replacement and kept SpO(2) within target range significantly better than manual control during subsequent ventilation. In ou...Continue Reading

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Citations

Apr 15, 2016·Molecular and Cellular Pediatrics·Matthias C HüttenBoris W Kramer
Sep 17, 2016·Archives of Disease in Childhood. Fetal and Neonatal Edition·Peter A DargavilleTimothy J Gale
Jun 20, 2019·Pediatric Research·Janneke DekkerArjan B Te Pas
Nov 13, 2019·Acta Paediatrica·Sarah SturrockAnne Greenough
Mar 2, 2019·Brain Sciences·Shiraz BadurdeenGraeme Polglase
Aug 1, 2020·Archives of Disease in Childhood. Fetal and Neonatal Edition·Hylke H SalverdaArjan B Te Pas
Jan 5, 2021·Current Opinion in Pediatrics·Souvik Mitra, Douglas McMillan
May 12, 2021·Archives of Disease in Childhood. Fetal and Neonatal Edition·Koen P DijkmanHendrik J Niemarkt

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