To review the epidemiology and characteristics of patients who died or underwent colectomy secondary to fulminant Clostridium difficile colitis. In patients with C. difficile colitis, a progressive, systemic inflammatory state may develop that is unresponsive to medical therapy; it may progress to colectomy or death. The authors reviewed 2,334 hospitalized patients with C. difficile colitis from January 1989 to December 2000. Sixty-four patients died or underwent colectomy for pathologically proven C. difficile colitis. In 2000, the incidence of C. difficile colitis in hospitalized patients increased from a baseline of 0.68% to 1.2%, and the incidence of patients with C. difficile colitis in whom life-threatening symptoms developed increased from 1.6% to 3.2%. Forty-four patients required a colectomy and 20 others died directly from C. difficile colitis. Twenty-two percent had a prior history of C. difficile colitis. A recent surgical procedure and immunosuppression were common predisposing conditions. Lung transplant patients were 46 times more likely to have C. difficile colitis and eight times more likely to have severe disease. Abdominal computed tomography scan correctly diagnosed all patients, whereas 12.5% of toxin assay...Continue Reading
Associated Clinical Trials
Inhibition of rat corticotropin-releasing factor and adrenocorticotropin secretion by an osmotic stimulus
Interaction between Clostridium difficile and polymorphonuclear leucocytes from the elderly and post-operative cancer patients: phagocytosis and bactericidal function
Diarrhoea caused by Clostridium difficile: response time for treatment with metronidazole and vancomycin
Survival of anti-Clostridium difficile bovine immunoglobulin concentrate in the human gastrointestinal tract
Increased substance P responses in dorsal root ganglia and intestinal macrophages during Clostridium difficile toxin A enteritis in rats
Recurrent Clostridium difficile diarrhea: characteristics of and risk factors for patients enrolled in a prospective, randomized, double-blinded trial
Fluconazole susceptibility and strain variation of Candida albicans isolates from HIV-infected patients with oropharyngeal candidosis
Practice of gastroenterologists in treating flaring inflammatory bowel disease patients with clostridium difficile: antibiotics alone or combined antibiotics/immunomodulators?
Who are susceptible to pseudomembranous colitis among patients with presumed antibiotic-associated diarrhea?
Review: Clostridium difficile-associated disorders/diarrhea and Clostridium difficile colitis: the emergence of a more virulent era
Effects of combination therapy with direct hemoperfusion using polymyxin B-immobilized fiber and oral vancomycin on fulminant pseudomembranous colitis with septic shock
Changing Clostridium difficile infection testing and treatment trends at a large tertiary care teaching hospital
Enterocolitis due to simultaneous infection with rotavirus and Clostridium difficile in adult and pediatric solid organ transplantation
Clostridium difficile colitis: factors associated with outcome and assessment of mortality at a national level
Chemotherapy patients with C. difficile colitis have outcomes similar to immunocompetent C. difficile patients
Predicting recurrence of C. difficile colitis using bacterial virulence factors: binary toxin is the key
Fulminant, non-antibiotic associated Clostridium difficile colitis following Salmonella gastroenteritis
Second European evidence-based consensus on the prevention, diagnosis and management of opportunistic infections in inflammatory bowel disease
Albumin, length of stay, and proton pump inhibitors: key factors in Clostridium difficile-associated disease in nursing home patients
Gastrointestinal disorders and the critically ill. Clostridium difficile infection and pseudomembranous colitis
A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality
A hospital outbreak of Clostridium difficile disease associated with isolates carrying binary toxin genes
A comparison of vancomycin and metronidazole for the treatment of Clostridium difficile-associated diarrhea, stratified by disease severity
High frequency of rifampin resistance identified in an epidemic Clostridium difficile clone from a large teaching hospital
Statewide experience with Clostridium difficile colitis in academic and non-academic medical centers
Surgical outcome of community-acquired Clostridium difficile colitis presenting as toxic megacolon: case report
Effective utilization of evolving methods for the laboratory diagnosis of Clostridium difficile infection
The impact of ICD-9-CM code rank order on the estimated prevalence of Clostridium difficile infections
Clostridium difficile diarrhoea in the immunosuppressed patient--update on prevention and management
Impact of emergency colectomy on survival of patients with fulminant Clostridium difficile colitis during an epidemic caused by a hypervirulent strain
Identification of risk factors for the development of clostridium difficile-associated diarrhea following treatment of polymicrobial surgical infections
Diverting loop ileostomy and colonic lavage: an alternative to total abdominal colectomy for the treatment of severe, complicated Clostridium difficile associated disease
In vitro and in vivo characterization of CB-183,315, a novel lipopeptide antibiotic for treatment of Clostridium difficile
Human monoclonal antibodies directed against toxins A and B prevent Clostridium difficile-induced mortality in hamsters
tcdC genotypes associated with severe TcdC truncation in an epidemic clone and other strains of Clostridium difficile
What is the current role of algorithmic approaches for diagnosis of Clostridium difficile infection?
Multilocus variable-number tandem-repeat analysis for investigation of Clostridium difficile transmission in Hospitals
Improved eradication of Clostridium difficile spores from toilets of hospitalized patients using an accelerated hydrogen peroxide as the cleaning agent
Acute fulminant pseudomembranous colitis which developed after ileostomy closure and required emergent total colectomy: a case report
Clostridium difficile 027-associated pseudomembranous colitis after short-term treatment with cefuroxime and cephalexin in an elderly orthopedic patient: a case report
Mortality attributable to nosocomial Clostridium difficile-associated disease during an epidemic caused by a hypervirulent strain in Quebec
Clostridium difficile-associated diarrhea in a region of Quebec from 1991 to 2003: a changing pattern of disease severity
An autopsy case of disseminated cryptococcosis manifesting as acute diarrhea in a patient with primary biliary cirrhosis
Cost-effectiveness of competing strategies for management of recurrent Clostridium difficile infection: a decision analysis
Characterization of Clostridium difficile isolates from human fecal samples and retail meat from Pennsylvania
Differences in outcome according to Clostridium difficile testing method: a prospective multicentre diagnostic validation study of C difficile infection
Clostridium difficile Infection (CDI) in Solid Organ and Hematopoietic Stem Cell Transplant Recipients
European evidence-based Consensus on the prevention, diagnosis and management of opportunistic infections in inflammatory bowel disease
Diagnosis of Clostridium difficile infection: an ongoing conundrum for clinicians and for clinical laboratories
Calcineurin inhibitors and Clostridium difficile infection in adult lung transplant recipients: the effect of cyclosporine versus tacrolimus
Evaluation of the rapid loop-mediated isothermal amplification assay Illumigene for diagnosis of Clostridium difficile in an outbreak situation
Infection Probability Score: a predictor of Clostridium difficile-associated disease onset in patients with haematological malignancy
Epidemiology, outcomes, and predictors of mortality in hospitalized adults with Clostridium difficile infection
Investigation of critical care unit utilization and mortality in patients infected with Clostridium difficile
Combination immunomodulator and antibiotic treatment in patients with inflammatory bowel disease and clostridium difficile infection
A case of toxic megacolon caused by clostridium difficile infection and treated with fecal microbiota transplantation
The challenge of Clostridium difficile infection: Overview of clinical manifestations, diagnostic tools and therapeutic options
Open-label, dose escalation phase I study in healthy volunteers to evaluate the safety and pharmacokinetics of a human monoclonal antibody to Clostridium difficile toxin A
Outcome of metronidazole therapy for Clostridium difficile disease and correlation with a scoring system
Clostridium difficile-associated diarrhea in heart transplant recipients: is hypogammaglobulinemia the answer?
Identification, optimal management, and infection control measures for Clostridium difficile-associated disease in long-term care
Epidemiology and incidence of Clostridium difficile-associated diarrhoea diagnosed upon admission to a university hospital
Clostridium difficile-associated disease: an emerging threat to patient safety: insights from the Society of Infectious Diseases Pharmacists
Fecal microbiota transplantation for fulminant Clostridium difficile infection in an allogeneic stem cell transplant patient
Outcome of Clostridium difficile-associated disease in solid organ transplant recipients: a prospective and multicentre cohort study
Impact of Clostridium difficile colitis following closure of a diverting loop ileostomy: results of a matched cohort study
Risk factors, preemptive therapy, and antiperistaltic agents for Clostridium difficile infection in cancer patients
Association of Clostridium difficile infection with outcomes of hospitalized solid organ transplant recipients: results from the 2009 Nationwide Inpatient Sample database
Systematic review and meta-analysis of outcomes following emergency surgery for Clostridium difficile colitis
Intravenous immunoglobulin for the treatment of severe Clostridium difficile colitis: an observational study and review of the literature
Are vasopressor use and mechanical ventilation the only predictors of worse outcome for fulminant Clostridium difficile infection?
Predictive factors associated with adverse events in patients with toxic colitis: an analysis of the National Surgical Quality Improvement Project
Clostridium difficile infection after allogeneic hematopoietic stem cell transplant: strain diversity and outcomes associated with NAP1/027
Clostridium difficile colitis in the United States: a decade of trends, outcomes, risk factors for colectomy, and mortality after colectomy
Clostridium difficile: a problem of concern in developed countries and still a mystery in Latin America
Changes in antibiotic susceptibility and ribotypes in Clostridium difficile isolates from southern Scotland, 1979-2004
Postoperative diarrhea and high ostomy output impact postoperative outcomes after elective colon and rectal operations regardless of Clostridium difficile infection
Attributable burden of hospital-onset Clostridium difficile infection: a propensity score matching study
Comparison of 2 Clostridium difficile surveillance methods: National Healthcare Safety Network's laboratory-identified event reporting module versus clinical infection surveillance
Comparison of the burdens of hospital-onset, healthcare facility-associated Clostridium difficile Infection and of healthcare-associated infection due to methicillin-resistant Staphylococcus aureus in community hospitals
Potential role of post-transplant hypogammaglobulinemia in the risk of Clostridium difficile infection after kidney transplantation: a case-control study
Predicting Clostridium difficile infection in diabetic patients and the effect of metformin therapy: a retrospective, case-control study
The role of immunoglobulin for the treatment of Clostridium difficile infection: a systematic review
Cost-effectiveness analysis evaluating fidaxomicin versus oral vancomycin for the treatment of Clostridium difficile infection in the United States
Fecal microbiota transplantation (FMT) for Clostridium difficile infection: focus on immunocompromised patients
Isolation and characterisation of toxin A-negative, toxin B-positive Clostridium difficile in Dublin, Ireland
European Society of Clinical Microbiology and Infectious Diseases: update of the treatment guidance document for Clostridium difficile infection
Impact of hydrogen peroxide vapor room decontamination on Clostridium difficile environmental contamination and transmission in a healthcare setting
Prevalence of Clostridium difficile infection among solid organ transplant recipients: a meta-analysis of published studies
Hospitalized Patients with Heart Failure and Common Bacterial Infections: A Nationwide Analysis of Concomitant Clostridium Difficile Infection Rates and In-Hospital Mortality
A new look at toxic megacolon: an update and review of incidence, etiology, pathogenesis, and management
Successful treatments with polymyxin B hemoperfusion and recombinant human thrombomodulin for fulminant Clostridium difficile-associated colitis with septic shock and disseminated intravascular coagulation: a case report
Clostridium difficile infection health disparities by race among hospitalized adults in the United States, 2001 to 2010
Risk factors for short- and long-term mortality in very old patients with Clostridium difficile infection: A retrospective study
Fecal microbiota transplant in severe and severe-complicated Clostridium difficile: A promising treatment approach
A large outbreak of Clostridium difficile-associated disease with an unexpected proportion of deaths and colectomies at a teaching hospital following increased fluoroquinolone use
Lack of association between the increased incidence of Clostridium difficile-associated disease and the increasing use of alcohol-based hand rubs
Population-based surveillance of Clostridium difficile infection in Manitoba, Canada, by using interim surveillance definitions
Multicenter study of surveillance for hospital-onset Clostridium difficile infection by the use of ICD-9-CM diagnosis codes
Diagnosis and outcome of Clostridium difficile infection by toxin enzyme immunoassay and polymerase chain reaction in an island population
Measuring the severity of Clostridium difficile infection: implications for management and drug development
Clostridium difficile: epidemiology, pathogenesis, management, and prevention of a recalcitrant healthcare-associated pathogen
Histologic findings and clinical characteristics in acutely symptomatic ulcerative colitis patients with superimposed Clostridium difficile infection
Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA)
Risk factors and management of refractory or recurrent clostridium difficile infection in ileal pouch patients
Metronidazole or Rifaximin for Treatment of Clostridium difficile in Pediatric Patients with Inflammatory Bowel Disease: A Randomized Clinical Trial
Comparative Study of Drainage and Antibiotics versus Drainage Only in the Management of Primary Subcutaneous Abscesses
Epidemiology and outcomes of Clostridium difficile infection in allogeneic hematopoietic cell and lung transplant recipients
Identifying predictive features of Clostridium difficile infection recurrence before, during, and after primary antibiotic treatment
Prevention and treatment of Clostridium difficile associated diarrhea by reconstitution of the microbiota
Enteric infection in relapse of inflammatory bowel disease: importance of microbiological examination of stool
Fecal microbiota transplantation for the treatment of recurrent and severe Clostridium difficile infection in solid organ transplant recipients: A multicenter experience
Epidemiology of Clostridium difficile colitis in hospitalized patients with inflammatory bowel diseases
Risk Factors Associated with Clostridium difficile Infection in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis
Factors Associated With Health Care Utilization of Recurrent Clostridium difficile Infection in New York State
The Rise and Fall and Rise Again of Toxin Testing for the Diagnosis of Clostridioides difficile Infection
Toxin Enzyme Immunoassays Detect Clostridioides difficile Infection With Greater Severity and Higher Recurrence Rates
Bacterial enteric infections in children: etiology, clinical manifestations and antimicrobial therapy
Obesity as protective against, rather than a risk factor for, postoperative Clostridium Difficile infection: A nationwide retrospective analysis of 1,426,807 surgical patients
Trends in Diverting Loop Ileostomy vs Total Abdominal Colectomy as Surgical Management for Clostridium difficile Colitis
The role of acute care surgery in the treatment of severe, complicated Clostridium difficile-associated disease
Fidaxomicin: a minimally absorbed macrocyclic antibiotic for the treatment of Clostridium difficile infections
Clostridium difficile infections in a university hospital in Greece are mainly associated with PCR ribotypes 017 and 126
Severe complicated Clostridium difficile infection: Can the UPMC proposed scoring system predict the need for surgery?
Development and validation of a clinical risk calculator for mortality after colectomy for fulminant Clostridium difficile colitis
Clostridium difficile colitis: increasing incidence, risk factors, and outcomes in solid organ transplant recipients
Limitations of the Infectious Disease Society of America/Society for Hospital Epidemiologists of America 2017 Update of Guidelines for the Treatment of Clostridium Difficile Colitis
Prevalence of Clostridium difficile infection among hospitalized inflammatory bowel disease patients in Greece
Resolution of severe Clostridium difficile infection following sequential fecal microbiota transplantation
Prevalent PCR ribotypes of clinical and environmental strains of Clostridium difficile isolated from intensive-therapy unit patients in Kuwait
Fecal Transplants by Colonoscopy and Capsules Are Cost-Effective Strategies for Treating Recurrent Clostridioides difficile Infection
The growing incidence and severity of Clostridium difficile infection in inpatient and outpatient settings
Risk factors for mortality following emergency colectomy for fulminant Clostridium difficile infection
Timing and type of surgical treatment of Clostridium difficile-associated disease: a practice management guideline from the Eastern Association for the Surgery of Trauma
Emergency subtotal colectomy for fulminant Clostridium difficile colitis--is a surgical solution considered for all patients?
Comparison of pediatric and adult antibiotic-associated diarrhea and Clostridium difficile infections
Association of Clostridioides difficile with adverse clinical outcomes in patients with acute diverticulitis: A nationwide study.
Current challenges in the treatment of severe Clostridium difficile infection: early treatment potential of fecal microbiota transplantation
Effects of a New Hospital-Wide Surgical Consultation Protocol in Patients with Clostridium difficile Colitis
Management of Clostridioides (formerly Clostridium) difficile infection (CDI) in solid organ transplant recipients: Guidelines from the American Society of Transplantation Community of Practice
Obesity as protective against, rather than a risk factor for, postoperative Clostridium difficile infection: A nationwide retrospective analysis of 1,426,807 surgical patients
Clostridium difficile Infection Is Associated With Lower Inpatient Mortality When Managed by GI Surgeons
2019 update of the WSES guidelines for management of Clostridioides (Clostridium ) difficile infection in surgical patients
Predictors of mortality after emergency colectomy for Clostridium difficile colitis: an analysis of ACS-NSQIP
Predictors of Mortality Among a National Cohort of Veterans With Recurrent Clostridium difficile Infection
Unique Clindamycin-Resistant Clostridioides difficile Strain Related to Fluoroquinolone-Resistant Epidemic BI/RT027 Strain
Fecal Microbiota Transplantation for Clostridioides difficile in High-Risk Older Adults Is Associated with Early Recurrence.
A 2-step algorithm combining glutamate dehydrogenase and nucleic acid amplification tests for the detection of Clostridioides difficile in stool specimens.
Colon Surgery Risk With Corticosteroids Versus Immunomodulators or Biologics in Inflammatory Bowel Disease Patients With Clostridium difficile Infection
Intracolonic Administration of Vancomycin in Intensive Care Unit Patients with Severe Clostridium Difficile Colitis
No survival advantage exists for patients undergoing loop ileostomy for clostridium difficile colitis
Mortality Following Clostridioides difficile Infection in Europe: A Retrospective Multicenter Case-Control Study.
Management of Severe and Severe/Complicated Clostridoides difficile Infection using Sequential Fecal Microbiota Transplant by Retention Enema.
The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Management of Clostridioides difficile Infection.
Endotoxin acts synergistically with C. difficile toxin B to increase IL-1 β production: A potential role for the intestinal biome in modifying the severity of C. difficile colitis.
Community-acquired fulminant Clostridioides (Clostridium) difficile infection by ribotype 027 isolate in Japan: a case report.
Immunosuppression and Clostridium difficile Infection Risk in Metabolic and Bariatric Surgery Patients.
Economic burden and cost-effectiveness of therapies for Clostridiodes difficile infection: a narrative review.
Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.
STING Receptor Agonists
Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.
Chronic Fatigue Syndrome
Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.
Hereditary Sensory Autonomic Neuropathy
Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.
Spatio-Temporal Regulation of DNA Repair
DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.
Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.
Separation anxiety is a type of anxiety disorder that involves excessive distress and anxiety with separation. This may include separation from places or people to which they have a strong emotional connection with. It often affects children more than adults. Here is the latest research on separation anxiety.
KIF1A Associated Neurological Disorder
KIF1A associated neurological disorder (KAND) is a rare neurodegenerative condition caused by mutations in the KIF1A gene. KAND may present with a wide range and severity of symptoms including stiff or weak leg muscles, low muscle tone, a lack of muscle coordination and balance, and intellectual disability. Find the latest research on KAND here.
Regulation of Vocal-Motor Plasticity
Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.