Fulminant hepatitis associated with hepatitis A virus superinfection in patients with chronic hepatitis C

The New England Journal of Medicine
S VentoE Concia

Abstract

Hepatitis A virus (HAV) infection rarely causes fulminant hepatic failure in people with no underlying liver disease. There are limited data on the course of this infection in patients with chronic hepatitis B and chronic hepatitis C. We prospectively followed, from June 1990 to July 1997, 595 adults with biochemical and histologic evidence of chronic hepatitis B (163 patients) or chronic hepatitis C (432 patients) who were seronegative for HAV antibodies. All were tested every four months for serum IgM and IgG antibodies to HAV. Twenty-seven patients acquired HAV superinfection, 10 of whom had chronic hepatitis B and 17 of whom had chronic hepatitis C. One of the patients with chronic hepatitis B, who also had cirrhosis, had marked cholestasis (peak serum bilirubin level, 28 mg per deciliter [479 micromol per liter]); the other nine had uncomplicated courses of hepatitis A. Fulminant hepatic failure developed in seven of the patients with chronic hepatitis C, all but one of whom died. The other 10 patients with chronic hepatitis C had uncomplicated courses of hepatitis A. Although most patients with chronic hepatitis B who acquired HAV infection had an uncomplicated course, patients with chronic hepatitis C had a substantial r...Continue Reading

Associated Clinical Trials

References

Apr 1, 1992·The Journal of Clinical Investigation·C FérayC Bréchot
Jun 12, 1990·Journal of Immunological Methods·M FusconiF B Bianchi
Oct 24, 1985·The New England Journal of Medicine·S M Lemon
Dec 1, 1985·Liver·N TassopoulosR H Purcell
Jul 1, 1983·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R ZachovalF Deinhardt
Aug 1, 1983·Digestive Diseases and Sciences·C ConteasB Weliky
Jan 1, 1982·Journal of Medical Virology·M BerningerJ L Gerin
Feb 1, 1982·Postgraduate Medical Journal·L A ViolaI M Murray-Lyon
Sep 1, 1981·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R G KnodellJ Wollman
Jan 1, 1994·Journal of Medical Virology·B M McFarlaneI G McFarlane
Jan 1, 1995·Gastroenterology·A J CzajaS B Moore

❮ Previous
Next ❯

Citations

Mar 21, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M H Sjogren
Sep 8, 2010·Inflammatory Bowel Diseases·Andrzej RadzikowskiPiotr Albrecht
Mar 17, 2000·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·M ArslanN N Zein
Sep 18, 2001·Current Infectious Disease Reports·Mark S. Sulkowski
Jul 27, 2007·Journal of Gastroenterology·Keiichi FujiwaraMasao Omata
May 27, 2009·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·V S de PaulaM A Pinto
Aug 23, 2005·Digestive Diseases and Sciences·R Jake JacobsSammy Saab
Mar 30, 2007·Virus Genes·Hakima Gharbi-KhelifiMahjoub Aouni
Nov 30, 2012·Bulletin of Mathematical Biology·Marcos AmakuEduardo Massad
Jan 18, 2003·Current Gastroenterology Reports·Javier Vaquero, Andres T Blei
Dec 20, 2012·Current Gastroenterology Reports·Michael D Leise, Jayant A Talwalkar
Aug 11, 2005·Current HIV/AIDS Reports·Mark S Sulkowski
Sep 22, 2007·Current HIV/AIDS Reports·Edgar Turner Overton
Nov 30, 2000·Current Infectious Disease Reports·M A Poles, D T Dieterich
Nov 30, 2000·Current Infectious Disease Reports·M P Epstein, T Knox
Nov 6, 2004·Current Treatment Options in Gastroenterology·Miguel R Arguedas, Michael B Fallon
Nov 30, 2005·Current Treatment Options in Gastroenterology·Jelica KurtovicRoger Williams
Nov 11, 2010·Hepatology International·Xiaohong ZhangZhiliang Gao
Apr 10, 2004·Drug and Alcohol Dependence·Gianluca QuaglioFabio Lugoboni
Nov 14, 1998·Disease-a-month : DM·H W HorowitzG P Wormser
Mar 12, 1999·The Surgical Clinics of North America·A O ShakilD J Kramer
Mar 29, 2002·Lancet·Klaus StarkUlrich Bienzle
Feb 28, 2004·Lancet·Luca Mascitelli, Francesca Pezzetta
Jun 10, 1998·Lancet·R S Koff
Jul 16, 2003·The Journal of Infection·S DevalleA M C Gaspar
Jun 19, 2002·FEMS Microbiology Reviews·Marion KoopmansSteve Monroe
Dec 22, 1999·Journal of Hepatology·S SchenkerA M Hoyumpa
Jan 6, 2000·Journal of Hepatology·F Zoulim
May 15, 2003·Vaccine·Piero L Almasio, Pietro Amoroso
Sep 15, 2000·Infectious Disease Clinics of North America·N M Kemmer, E P Miskovsky
Sep 15, 2000·Infectious Disease Clinics of North America·M A Poles, D T Dieterich
Sep 15, 2000·Infectious Disease Clinics of North America·H R Rosen, P Martin
Mar 16, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Robert J FontanaMitchell L Shiffman
Oct 31, 2002·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·T StroffoliniA Craxi
Jul 19, 2003·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·E BiancoUNKNOWN SEIEVA Collaborating Group
May 30, 2012·Nature Reviews. Gastroenterology & Hepatology·Daniel Shouval
Oct 29, 1998·British Journal of Haematology·P L Giangrande
Jul 10, 2001·Haemophilia : the Official Journal of the World Federation of Hemophilia·M MakrisUNKNOWN Transfusion Transmitted Infection Working Party of the UK Haemophilia Centre Directors Organization
Jan 6, 2000·Journal of Intellectual Disability Research : JIDR·A VellingaA Meheus

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Emmet B KeeffeD S Krause
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
M R ArguedasM B Fallon
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
M H Sjogren
© 2021 Meta ULC. All rights reserved