Fulminant intravascular lymphoma presenting as fever of unknown origin

Leukemia & Lymphoma
Aliza ZeidmanOkon Elimelech

Abstract

Intravascular large cell lymphoma (IVLL) is a rare neoplasm characterized by the proliferation of malignant lymphoid cells within the lumens of small to medium-sized blood vessels. The central nervous system, skin, and endocrine systems are most commonly involved. IVLL may disseminate to the heart, pancreas, liver, spleen, kidneys, and adrenal glands. We report a 52-year-old patient who was admitted for fever of unknown origin for 3 weeks, jaundice and abnormal liver function tests. Fever, high levels of bilirubin, severe anemia, thrombocytopenia, and a very fulminant course characterized the clinical picture. Although bone marrow involvement is quite rare, the diagnosis of IVLL in this patient was done by bone marrow biopsy. The patient was treated with CHOP protocol and received the first course but the aggressive disease led to the patient's death.

References

Dec 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J A DiGiuseppeR B Mann
Dec 24, 2002·The American Journal of the Medical Sciences·Madhuri YalamanchiliJames Walsh
Jan 25, 2003·The American Journal of Medicine·Sharlene GillClifford ChanYan
Mar 12, 2003·International Journal of Hematology·Masafumi ItoMasahiko Fujino
Jun 5, 2003·Journal of Clinical Pathology·P C W LuiG M K Tse

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Citations

Oct 9, 2007·Brain Pathology·Michel MittelbronnRudi Beschorner
Sep 23, 2018·European Journal of Nuclear Medicine and Molecular Imaging·Abdullah Al-ZaghalAbass Alavi
Jan 14, 2009·Journal of Neuro-oncology·Salih Bin SalihVejy Palker

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