Fulminant liver failure following infection by Clostridium perfringens

Surgical Infections
Hendrik BergertDetlef Ockert

Abstract

Since the first description of gas gangrene of an internal organ by Fraenkel in 1889, few cases of acute organ failure following Clostridium perfringens infection have been described in the medical literature. Isolated Clostridium perfringens infection with subsequent sepsis syndrome is an extremely rare clinical syndrome. A consecutive pattern of multiple organ failure generally has a very high mortality rate. Individual case report and literature review. A 58-year-old male patient developed fulminant necrotic liver failure following a Clostridium perfringens infection. Despite all intensive care measures, including computed tomography-guided drainage, the condition of the patient deteriorated rapidly and the patient died. In this case report, we characterize the symptoms of gas gangrene isolated to the liver and compare the treatment measures instituted with the medical literature. In our presented case, primary malignant disease of the papilla of Vater and resection by a Whipple procedure with a hepatico-jejunostomy were a decisive cause of the gas gangrene in the liver. The origin is probably ascension up the common hepatic duct of gut-derived bacteria.

References

Jul 1, 1976·Archives of Internal Medicine·E S Caplan, R M Kluge
Nov 1, 1994·World Journal of Surgery·H J MischingerE Deu
May 1, 1996·Annals of Surgery·C J HuangG D Zuidema
Nov 1, 1996·Seminars in Liver Disease·N RolandoR Williams
Dec 31, 1997·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·P BeckerhinnC Schrutka-Kölbl
Mar 13, 1999·The Australian and New Zealand Journal of Surgery·M S BarakateD M Sheldon
Jul 11, 2001·Critical Care Medicine·J F DhainautC Vinsonneau

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Citations

Feb 2, 2011·The Review of Scientific Instruments·S LukicM C R Zoll
Jul 19, 2008·World Journal of Gastroenterology : WJG·Yukihiro Shimizu
Oct 3, 2014·World Journal of Hepatology·Masami MinemuraYukihiro Shimizu
Jan 4, 2008·Surgical Infections·Ingmar KönigsrainerAlfred Königsrainer
Apr 25, 2009·Surgical Infections·Walther TabarelliEtienne Wenzl
Feb 2, 2019·World Journal of Hepatology·Hassan TariqHarish Patel
Oct 15, 2009·Future Microbiology·Michel R Popoff, Philippe Bouvet

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