PMID: 4286342Mar 11, 1966Paper

Fumarate reductase in the control of heme biosynthesis

Science
T Kurumada, R F LABBE

Abstract

A drug-induced stimulation of heme biosynthesis in mouse liver was accompanied by altered fumarate metabolism. In liver homogenate, fumarate 1,4-C(14) was incorporated, via succinate and succinyl coenzyme A, into heme at an accelerated rate. This pathway of fumarate utilization was inhibited by acetoacetate but not by beta-hydroxybutyrate. Fumarate reduction to succinate required reduced nicotinamide adenine dinucleotide. The enzyme fumarate reductase is suggested as a link between terminal oxidation and cellular control of the heme biosynthetic pathway.

References

Dec 16, 1965·Biochimica Et Biophysica Acta·R F LabbeJ Onisawa
Dec 16, 1965·Biochimica Et Biophysica Acta·T Kurumada, R F Labbe
Mar 1, 1962·Archives of Biochemistry and Biophysics·M L COWGERB MACKLER
Jun 21, 1963·Science·J ONISAWA, R F LABBE
Apr 1, 1963·Archives of Biochemistry and Biophysics·M L COWGERM SEWELL
Apr 1, 1965·Proceedings of the National Academy of Sciences of the United States of America·D P TSCHUDYM RECHCIGL

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Citations

Aug 1, 1968·British Journal of Haematology·S S Zail, S M Joubert
May 1, 1968·British Journal of Haematology·R J ColeJ Paul
May 6, 1969·Biochimica Et Biophysica Acta·C B Vaughn, J M Orten
Sep 26, 2020·International Journal of Molecular Sciences·Jennifer F CarrPhyllis A Dennery
Jun 1, 1967·Journal of Bacteriology·B J Aue, R H Deiel

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