Fumigaclavine C improves concanavalin A-induced liver injury in mice mainly via inhibiting TNF-alpha production and lymphocyte adhesion to extracellular matrices

The Journal of Pharmacy and Pharmacology
Ying ZhaoQiang Xu

Abstract

Fumigaclavine C, an alkaloidal metabolite, was produced by Aspergillus fumigatus (strain No. CY018). This study examined the effect of this compound on concanavalin A (Con A)-induced liver injury in mice, a T cell-dependent model of liver damage. Con A administration resulted in severe liver injury, T lymphocyte activation and a strong increment in spleen cell adhesion, as well as in tumour necrosis factor-alpha (TNF-alpha) production. Against this liver injury, the intraperitoneal administration of fumigaclavine C dose-dependently inhibited the elevation in transaminase activity, TNF-alpha production in serum and the histological changes, including inflammatory infiltration, hepatocyte necrosis and degeneration and Kupffer cell hyperplasia. In addition, this compound in-vitro also inhibited the proliferation of spleen cells induced by Con A, and reduced their IL-2 and TNF-alpha production. Moreover, the intraperitoneal administration of fumigaclavine C inhibited the potential of spleen cells isolated from the liver-injured mice to adhere to fibronectin, laminin and type IV collagen. These results suggest that the improvement of this T cell-mediated liver injury by fumigaclavine C may be related to the inhibition of lymphocyte ...Continue Reading

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Citations

Oct 1, 2009·Mycotoxin Research·Hadri LatifEwald Usleber
Dec 6, 2008·Parasitology Research·Maria Irma Seixas DuarteFelipe Francisco Tuon
Feb 3, 2007·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Zainul Amiruddin ZakariaFatimah Corazon Abdullah
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Mar 17, 2017·Natural Product Reports·Haichao Liu, Yanxing Jia
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