Fumonisin B1 facilitates seizures induced by pentylenetetrazol in mice

Neurotoxicology and Teratology
A B PoerschA F Furian

Abstract

Fumonisin B1 (FB1) is a Fusarium spp. mycotoxin which constitutes a major public health issue because of its worldwide distribution and diversity of toxic effects.While the liver and kidney are considered the major target organs of FB1 toxicity in several species, evidence indicates that FB1 may be toxic to the brain. To further investigate the effects of FB1 on the central nervous system the present study aimed to test the hypothesis that acute FB1 exposure causes brain hyperexcitability and the potential underlying mechanisms. For these purposes, adult male C57BL/6 mice were injected with FB1 (8 mg/kg, i.p.) or its vehicle and 30 min thereafter received with a low dose of the classical convulsant pentylenetetrazol (PTZ, 30 mg/kg, i.p.) or its vehicle. After behavioral evaluation the cerebral cortex and the hippocampus were collected for analysis of Na(+),K(+)-ATPase activity, mitochondrial membrane potential (ΔΨm) and mitochondrial complex I and II activities. We found that FB1 reduced the latency for PTZ-induced myoclonic jerks and increased the number of these events. After exposure to FB1 total and α1 Na(+),K(+)-ATPase activities increased in cerebral cortex, whereas the same enzyme activities decreased in the hippocampus....Continue Reading

References

Oct 1, 1976·FEBS Letters·K E Akerman, M K Wikström
Jul 1, 1992·Toxicon : Official Journal of the International Society on Toxinology·G S ShephardW C Gelderblom
Apr 1, 1992·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·G S ShephardE W Sydenham
Nov 29, 1985·Clinica Chimica Acta; International Journal of Clinical Chemistry·J C FischerA J Janssen
Aug 1, 1995·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·G BondyR Mueller
Mar 1, 1997·Neurotoxicology and Teratology·O S KwonW Slikker
Jan 1, 1997·Journal of Toxicology. Clinical Toxicology·R V BhatR V Sudershan
Nov 25, 1998·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·M TsunodaR P Sharma
Sep 25, 2001·Toxicology·H S Hussein, J M Brasel
Feb 26, 2004·Free Radical Biology & Medicine·Li-Ping Liang, Manisha Patel
Mar 31, 2009·International Journal of Molecular Sciences·Selma Yazar, Gülden Z Omurtag
Aug 10, 2010·Neurobiology of Disease·Sarah WillisKarin Borges
Mar 15, 2011·The International Journal of Biochemistry & Cell Biology·Ana-Marija Domijan, Andrey Y Abramov
May 3, 2011·Mitochondrion·Jaroslava Folbergrová, Wolfram S Kunz

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Citations

Sep 22, 2017·Human Molecular Genetics·Jasmine M McCammonHazel Sive
Sep 5, 2018·IUBMB Life·Muhammad Torequl IslamAna Amélia de Carvalho Melo-Cavalcante
Sep 29, 2018·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Micheli DassiAna F Furian
Oct 2, 2019·Archives of Toxicology·Chongshan DaiTony Velkov
Feb 7, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Lili HouKehe Huang
Dec 15, 2019·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Kota NakajimaMakoto Shibutani
Jun 21, 2020·Neurotoxicology·Veronika BódiPetra Varró
Aug 14, 2021·Ecotoxicology and Environmental Safety·Yue WangShao-Chen Sun

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