PMID: 9540787Apr 16, 1998Paper

Function and conformation of wild-type p53 protein are influenced by mutations in bovine leukemia virus-induced B-cell lymphosarcoma

Virology
S TajimaY Aida

Abstract

The mutations of the p53 gene previously represented one of several genetic changes involved in the development of bovine leukemia virus (BLV)-induced lymphosarcoma, while the effects of these mutations on the function of p53 are unknown. We identified four mutations of p53 gene in BLV-infected cattle with lymphosarcoma and demonstrated clearly the existence of two functionally distinct groups of mutants: (i) the mutant forms with substitutions at codons 241 and 242, which were mapped within an evolutionally conserved region and corresponded to the human "hot-spot" mutations, had completely lost the capacities for transactivation and growth suppression and gained transdominant repression activity in p53-null SAOS-2 cells; and (ii) the mutations at codons 206 and 207 were located outside the evolutionally conserved regions. These mutants partially retained the capacity for transactivation and growth suppression and failed to inhibit the transactivation activity of coexpressed wild-type p53, instead showing an enhancement of this activity. In addition, protein analysis using an antibody specific for the mutant form revealed that the mutations at codons 206 and 242 induced a "mutant" conformation of the bovine p53 proteins. Collec...Continue Reading

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Citations

Sep 14, 2001·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·B MayrW Hochsteiner
Nov 18, 2000·AIDS Research and Human Retroviruses·L WillemsR Kettmann
Jun 3, 2008·Veterinary Immunology and Immunopathology·Arnaud FlorinsLuc Willems
Feb 11, 2015·Veterinary Research Communications·Farhid HemmatzadehJagoda Ignjatovic
Aug 5, 2016·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Kyung Jin EohEun Ji Nam

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