Function and Regulation of Cph2 in Candida albicans

Eukaryotic Cell
S LaneHaoping Liu

Abstract

Candida albicans is associated with humans as both a harmless commensal organism and a pathogen. Cph2 is a transcription factor whose DNA binding domain is similar to that of mammalian sterol response element binding proteins (SREBPs). SREBPs are master regulators of cellular cholesterol levels and are highly conserved from fungi to mammals. However, ergosterol biosynthesis is regulated by the zinc finger transcription factor Upc2 in C. albicans and several other yeasts. Cph2 is not necessary for ergosterol biosynthesis but is important for colonization in the murine gastrointestinal (GI) tract. Here we demonstrate that Cph2 is a membrane-associated transcription factor that is processed to release the N-terminal DNA binding domain like SREBPs, but its cleavage is not regulated by cellular levels of ergosterol or oxygen. Chromatin immunoprecipitation sequencing (ChIP-seq) shows that Cph2 binds to the promoters of HMS1 and other components of the regulatory circuit for GI tract colonization. In addition, 50% of Cph2 targets are also bound by Hms1 and other factors of the regulatory circuit. Several common targets function at the head of the glycolysis pathway. Thus, Cph2 is an integral part of the regulatory circuit for GI colon...Continue Reading

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Citations

Apr 8, 2016·The Journal of Biological Chemistry·Risa BurrPeter J Espenshade
Jun 2, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Longfei YangTonghui Ma
Aug 2, 2020·Scientific Reports·Renata Serignoli FrancisconiDenise Madalena Palomari Spolidorio
Aug 31, 2017·Seminars in Cell & Developmental Biology·Risa Burr, Peter J Espenshade

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