Function and regulation of Staphylococcus aureus wall teichoic acids and capsular polysaccharides

International Journal of Medical Microbiology : IJMM
Daniela KeinhörsterChristiane Wolz

Abstract

Staphylococcus aureus produces different secondary cell wall glycopolymers such as wall teichoic acids (WTA) and capsular polysaccharides (CP). These structures play an important role in S. aureus colonization, pathogenesis and bacterial evasion of the host immune defences. To fulfil their diverse functions, biosynthesis of both glycopolymers has to be tightly controlled. Regulation of WTA biosynthesis and modification is only partially understood. The transcription factor MgrA and the two-component systems (TCS) Agr, GraRS, and ArlRS control WTA export, chain-length and modification. CP synthesis is determined by transcriptional and post-transcriptional regulatory circuits. On the transcriptional level expression of the capA-P operon is mainly driven by the alternative Sigma factor B and modulated by several transcriptional factors and TCS. Post-transcriptional mechanisms are in place to avoid conflict between precursor usage by the CP synthesis machinery and the synthesis machinery of other cell wall glycopolymers. The complex interplay of these regulatory systems determines the peculiar, strictly temporal expression of CP in the late growth phase and the high degree of phenotypic heterogeneity. Differential expression of CP,...Continue Reading

References

Feb 1, 1991·Applied and Environmental Microbiology·W T StringfellowJ M Fournier
Jul 1, 1990·Carbohydrate Research·M MoreauW F Vann
Sep 1, 1987·Annales De L'Institut Pasteur. Microbiology·J M FournierW F Vann
Dec 1, 1987·The Journal of Infectious Diseases·R D Arbeit, R M Dunn
Feb 1, 1987·The Journal of Infectious Diseases·R D Arbeit, M J Nelles
Jul 1, 1984·Infection and Immunity·J M FournierW W Karakawa
Sep 1, 1983·Archives of Microbiology·J EndlK H Schleifer
May 1, 1997·Clinical and Diagnostic Laboratory Immunology·B PoutrelP Sarradin
Jan 18, 2002·Infection and Immunity·Thanh LuongChia Y Lee
Dec 11, 2003·Microbiology and Molecular Biology Reviews : MMBR·Francis C Neuhaus, James Baddiley
Jan 17, 2004·Clinical Microbiology Reviews·Katherine O'Riordan, Jean C Lee
Jun 19, 2004·Journal of Bacteriology·Markus BischoffSteven Projan
Jun 23, 2005·International Journal of Medical Microbiology : IJMM·Christiane GoerkeChristiane Wolz
Nov 18, 2005·Journal of Bacteriology·Samuel KatzifWilliam M Shafer
Nov 22, 2005·Infection and Immunity·Lorena P N TuchscherrDaniel O Sordelli
Jan 20, 2006·Molecular Microbiology·Jordan L CocchiaroJean C Lee
Mar 30, 2006·Antimicrobial Agents and Chemotherapy·Kati SeidlMarkus Bischoff
Apr 29, 2006·International Journal of Medical Microbiology : IJMM·Jan Pané-FarréMichael Hecker
May 5, 2006·Journal of Bacteriology·Tomaz KoprivnjakJerrold P Weiss
Jun 28, 2006·Proceedings of the National Academy of Sciences of the United States of America·Rachel M McLoughlinJean C Lee
Feb 19, 2008·Journal of Bacteriology·Timothy C MeredithSuzanne Walker
Mar 11, 2008·Nature Reviews. Microbiology·Christopher Weidenmaier, Andreas Peschel

❮ Previous
Next ❯

Citations

Oct 14, 2020·Microbial Genomics·Jaya SrivastavaPetety V Balaji
Dec 10, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Satu Mikkola
Oct 21, 2020·Journal of Bacteriology·Mei G Lei, Chia Y Lee
Feb 14, 2021·Current Opinion in Microbiology·Ankita J Sachla, John D Helmann
Dec 30, 2020·Chemical Reviews·Jed F Fisher, Shahriar Mobashery
Dec 4, 2020·FEMS Microbiology Reviews·Xia WuJian Zha

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

© 2021 Meta ULC. All rights reserved