PMID: 9534047Apr 16, 1998Paper

Function and specificity of human natural killer cell receptors

European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics
A MorettaR Millo

Abstract

In humans, natural killer lymphocytes express HLA class I-specific inhibitory receptors belonging to at least two different molecular families. The first is represented by members of the Ig superfamily that are involved in the recognition of different groups of HLA class I alleles, and the second is represented by a molecular complex formed by CD94 and NKG2A that displays a broad specificity for various class I molecules including the 'non-classical' HLA-G molecules. In addition to the inhibitory receptors, a series of activating receptors has been identified. Some display the same specificities as the corresponding inhibiting receptors and can be viewed as HLA class I-specific activating receptors. Another group of activating receptors appear to be involved in the cytolytic activity against HLA-'negative' target cells. These receptors are clearly non-MHC specific and, under physiological conditions, their function is suppressed by the HLA class I-specific inhibitory receptors.

Citations

Apr 9, 2015·Frontiers in Immunology·Harry PetrushkinGraham R Wallace
Apr 3, 2016·The British Journal of Dermatology·M BattistellaL Michel

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