Function and survival of renal allografts from the same donor transplanted into kidney-only or kidney-pancreas recipients

Transplantation
F G CosioR M Ferguson

Abstract

The aim of this study was to assess whether kidney-pancreas transplantation (KPT) compromises the prognosis of kidney transplantation (KT). This study included 368 paired recipients who received grafts from the same donor (184 KPT/184 KT), i.e., renal grafts with the same pretransplant functional and pathologic characteristics. KPT recipients (KPR) were significantly younger and included fewer African-Americans (22% vs. 6%, P=0.0005) than recipients of kidney alone (KR). During year 1 after transplant surgery, KPR were re-admitted more often than KR (4.2+/-2 vs. 2.8+/-2, P < 0.0001). The number of acute rejections (AR) and the serum creatinine were not significantly different in KR and KPR up to 3 years after transplant. After 44+/-29 months, 13% of KR and 17% of KPR died (NS), and 17% of KR and 16% of KPR lost their kidneys (NS). In KPR, reduced renal graft survival did not correlate with AR (P=0.44), but it correlated with: older donors, younger recipients, elevated serum creatinine at 6 months, pancreas loss, and the number of episodes of acute graft dysfunction evaluated by biopsy (multivariate analysis). By Cox, graft and patient survival were not significantly different in KR and KPR. However, the patient survival of KPR ...Continue Reading

References

Jan 1, 1988·Transplantation·M L HenryR M Ferguson
Apr 1, 1995·Kidney International·F G CosioR M Ferguson
Nov 1, 1995·Kidney International·M E Williams
Mar 1, 1996·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J D PirschM R Weir
Jun 15, 1996·Transplantation·J D PirschF O Belzer
Dec 1, 1996·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R J StrattaI S Gill
Apr 15, 1997·Transplantation·A T ArmstrongC G Orosz

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Citations

Apr 17, 2001·Annals of Surgery·D E SutherlandJ S Najarian

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