Function of Ech hydrogenase in ferredoxin-dependent, membrane-bound electron transport in Methanosarcina mazei.

Journal of Bacteriology
Cornelia WelteU Deppenmeier

Abstract

Reduced ferredoxin is an intermediate in the methylotrophic and aceticlastic pathway of methanogenesis and donates electrons to membrane-integral proteins, which transfer electrons to the heterodisulfide reductase. A ferredoxin interaction has been observed previously for the Ech hydrogenase. Here we present a detailed analysis of a Methanosarcina mazei Delta ech mutant which shows decreased ferredoxin-dependent membrane-bound electron transport activity, a lower growth rate, and faster substrate consumption. Evidence is presented that a second protein whose identity is unknown oxidizes reduced ferredoxin, indicating an involvement in methanogenesis from methylated C(1) compounds.

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Citations

Apr 12, 2011·Journal of Bacteriology·Cornelia Welte, Uwe Deppenmeier
Jul 10, 2013·Journal of Bacteriology·Ricardo Jasso-ChávezJames G Ferry
Jul 26, 2011·BMC Microbiology·Mingyu WangJames G Ferry
Mar 28, 2013·Archaea : an International Microbiological Journal·Patrick D Browne, Hinsby Cadillo-Quiroz
Jun 10, 2010·Annual Review of Microbiology·James G Ferry
Jul 16, 2010·The FEBS Journal·Cornelia WelteUwe Deppenmeier
Dec 18, 2013·Biochimica Et Biophysica Acta·Cornelia Welte, Uwe Deppenmeier
Oct 15, 2013·FEMS Microbiology Reviews·Florian Mayer, Volker Müller
Mar 6, 2012·Biochimica Et Biophysica Acta·Rouslan G Efremov, Leonid A Sazanov
Sep 3, 2013·European Journal of Medicinal Chemistry·Xiaochun GaoTao Xi
Sep 13, 2014·Current Opinion in Structural Biology·Wulf Blankenfeldt, James F Parsons
Jun 21, 2018·Annual Review of Microbiology·Volker MüllerMirko Basen
Aug 27, 2013·Journal of Bacteriology·Fabio O Morais-SilvaClaudina Rodrigues-Pousada
Apr 29, 2016·Microbiology and Molecular Biology Reviews : MMBR·Chris GreeningColin J Jackson
Oct 21, 2019·Cellular and Molecular Life Sciences : CMLS·Marie Charlotte Schoelmerich, Volker Müller
Sep 22, 2019·Journal of Biotechnology·Laura Sofie Nissen, Mirko Basen

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