Function of microRNA-375 and microRNA-124a in pancreas and brain

The FEBS Journal
Nadine Baroukh, Emmanuel van Obberghen

Abstract

In recent years, our understanding of how gene regulatory networks control cell physiology has improved dramatically. Studies have demonstrated that transcription is regulated not only by protein factors, but also by small RNA molecules, microRNAs (miRNAs). The first miRNA was discovered in 1993 as a result of a genetic screen for mutations in Caenorhabditis elegans. Since then, the use of sophisticated techniques and screening tools has promoted a more definitive understanding of the role of miRNAs in mammalian development and diseases. miRNAs have emerged as important regulators of genes involved in many biological processes, including development, cell proliferation and differentiation, apoptosis and metabolism. Over the last few years, the number of reviews dealing with miRNAs has increased at an impressive pace. In this review, we present general information on miRNA biology and focus more closely on comparing the expression, regulation and molecular functions of the two miRNAs, miR-375 and miR-124a. miR-375 and miR-124a share similar features; they are both specifically expressed in the pancreas and brain and directly bind a common target gene transcript encoding myotrophin, which regulates exocytosis and hormone release....Continue Reading

References

Sep 6, 2000·Trends in Genetics : TIG·R C Hardison
Mar 10, 2001·Nature·E S LanderUNKNOWN International Human Genome Sequencing Consortium
May 15, 2002·Current Biology : CB·Mariana Lagos-QuintanaThomas Tuschl
Aug 29, 2002·The EMBO Journal·Yoontae LeeV Narry Kim
Dec 6, 2002·Nature·UNKNOWN Mouse Genome Sequencing ConsortiumEric S Lander
Dec 18, 2002·The Journal of Cell Biology·Sudhiranjan GuptaSubha Sen
Feb 20, 2003·RNA·Victor AmbrosThomas Tuschl
Sep 26, 2003·Nature·Yoontae LeeV Narry Kim
Oct 22, 2003·Cell·Dianne S SchwarzPhillip D Zamore
Oct 22, 2003·Cell·Anastasia KhvorovaSumedha D Jayasena
Nov 25, 2003·Science·Elsebet LundUlrike Kutay
Dec 19, 2003·Genes & Development·Rui YiBryan R Cullen
Dec 19, 2003·Nucleic Acids Research·Sam Griffiths-Jones
Dec 31, 2003·Cell·Benjamin P LewisChristopher B Burge
Jan 8, 2004·Genome Biology·Anton J EnrightDebora S Marks
May 12, 2004·FEBS Letters·Amar AbderrahmaniGérard Waeber
Oct 27, 2004·PLoS Biology·Bino JohnDebora S Marks
Nov 13, 2004·Nature·Matthew N PoyMarkus Stoffel
Apr 5, 2005·Nature Genetics·Azra KrekNikolaus Rajewsky
Apr 30, 2005·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Nadine BaroukhLen A Pennacchio
May 28, 2005·Science·Erno WienholdsRonald H A Plasterk
Jun 7, 2005·Nature Cell Biology·Jidong LiuRoy Parker
Jun 24, 2005·Nature·Thimmaiah P ChendrimadaRamin Shiekhattar
Oct 15, 2005·Science·Jesse F AbelsonMatthew W State
Oct 15, 2005·Development·Tingting Du, Phillip D Zamore
Nov 17, 2005·Proceedings of the National Academy of Sciences of the United States of America·Alla Grishok, Phillip A Sharp
Nov 26, 2005·Science·Kyle Kai-How FarhDavid P Bartel
Feb 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Cecilia ConacoGail Mandel
Feb 24, 2006·Nature Reviews. Molecular Cell Biology·Cullen M TaniguchiC Ronald Kahn
Mar 3, 2006·Genes & Development·Marco Antonio Valencia-SanchezRoy Parker
Jun 1, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Monika DeoDavid L Turner
Nov 28, 2006·Nature Structural & Molecular Biology·Stephanie NottrottJoel D Richter

❮ Previous
Next ❯

Citations

Feb 12, 2013·Pflügers Archiv : European journal of physiology·Toni R PakNatasha N Mott
Jan 31, 2013·Archives of Pharmacal Research·Seung-Yoon ParkWan Lee
Apr 23, 2013·Trends in Endocrinology and Metabolism : TEM·Maria HatziapostolouDimitrios Iliopoulos
Mar 23, 2012·Nature Reviews. Molecular Cell Biology·Veerle Rottiers, Anders M Näär
Sep 1, 2011·The Journal of Biological Chemistry·Sanjay YadavDevendra Parmar
Sep 21, 2013·Pancreas·Anting Liu CarlsenNiels H H Heegaard
Jul 24, 2014·Genome Biology and Evolution·Teshome Tilahun Bizuayehu, Igor Babiak
Mar 28, 2013·Acta Diabetologica·Cinzia CiccacciPaola Borgiani
May 12, 2011·Expert Opinion on Therapeutic Targets·Yanjun XuTianhua Zhou
Sep 25, 2010·Joint, Bone, Spine : Revue Du Rhumatisme·Isabelle Duroux-RichardFlorence Apparailly
Mar 13, 2016·Clinical Biochemistry·Timothy Hudson RainerColin A Graham
Jun 20, 2014·Wiley Interdisciplinary Reviews. RNA·Chiranjib ChakrabortyGovindasamy Agoramoorthy
Jun 5, 2015·Frontiers in Cellular Neuroscience·Yang SunXia Liu
Jul 20, 2012·Epigenetics : Official Journal of the DNA Methylation Society·Elizabeth R Gilbert, Dongmin Liu
Jul 3, 2013·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Yiping MaoXiaoqing Tang
Apr 28, 2016·Progress in Neuro-psychopharmacology & Biological Psychiatry·Julia Hernandez-RappSébastien S Hébert
Dec 9, 2016·Journal of Human Genetics·Naoko Hashimoto, Tomoaki Tanaka
Oct 24, 2019·FEBS Letters·Markian PryshliakHenry Fechner
Jun 14, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Yang WangLin Liu
Dec 14, 2017·International Journal of Molecular Sciences·Loredana LeggioNunzio Iraci
Oct 12, 2012·Protein & Cell·Munish KumarYong Li
Jul 10, 2013·Experimental and Therapeutic Medicine·Jia ChengShiwei Duan
Mar 27, 2020·International Journal of General Medicine·Mohsen AghaeiEmad Babakhanzadeh
Oct 5, 2017·Genes & Nutrition·Giuseppe Iacomino, Alfonso Siani

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Matthew N PoyMarkus Stoffel
© 2021 Meta ULC. All rights reserved